Prognostic implications of changes in cardiac troponin I levels in patients with non-ST elevation acute coronary syndrome. (December 2013)

• Record Type: Journal Article
• Authors: Eggers, Kai M.; James, Stefan; Venge, Per; Lindahl, Bertil
• Is Part Of: Biomarkers. Volume 18:Number 8(2013)
• Page Start: 668
• Page End: 672
• Publication Date: 2013-12
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2013.843023
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: Information is limited on the prognostic implications of cardiac troponin I (cTnI) changes during the first days of non-ST elevation acute coronary syndrome (NSTE-ACS).</p> <p> <italic>Methods</italic>: High-sensitivity cTnI levels were measured at study inclusion and after 48 h in 1615 conservatively managed NSTE-ACS patients from the Global Use of Strategies To Open Occluded Coronary Arteries (GUSTO) IV trial.</p> <p> <italic>Results</italic>: Patients with moderately increased cTnI levels and without a relevant decrease over time had a significantly raised mortality at 30 days and 1 year. No relevant associations between cTnI changes and recurrent myocardial infarction were seen.</p> <p> <italic>Conclusion</italic>: The cTnI change is predictive for subsequent mortality in selected conservatively managed NSTE-ACS patients.</p> </abstract>