Screen time behaviours may interact with obesity genes, independent of physical activity, to influence adolescent BMI in an ethnically diverse cohort. Issue 6 (30th August 2013)

• Record Type: Journal Article
• Authors: Graff, M.; North, K. E.; Richardson, A. S.; Young, K. M.; Mohlke, K. L.; Lange, L. A.; Lange, E. M.; Harris, K. M.; Gordon‐Larsen, P.
• Is Part Of: Pediatric obesity. Volume 8:Issue 6(2013:Dec.)
• Page Start: e74
• Page End: e79
• Publication Date: 2013-08-30
• Subjects: Obesity in children -- Periodicals; Obesity in adolescence -- Periodicals; Obesity -- Periodicals; Overweight children -- Periodicals; 618.92398
• DOI: 10.1111/j.2047-6310.2013.00195.x
• Languages: English
• ISSNs: 1747-7174

Abstract

<abstract abstract-type="main"> <title>Summary</title> <sec id="ijpo195-sec-0001" sec-type="section"> <title>Background</title> <p>There has been little investigation of gene‐by‐environment interactions related to sedentary behaviour, a risk factor for obesity defined as leisure screen time (ST; i.e. television, video and computer games).</p> </sec> <sec id="ijpo195-sec-0002" sec-type="section"> <title>Objective</title> <p>To test the hypothesis that limiting ST use attenuates the genetic predisposition to increased body mass index (BMI), independent of physical activity.</p> </sec> <sec id="ijpo195-sec-0003" sec-type="section"> <title>Design</title> <p>Using 7642 wave II participants of the National Longitudinal Study of Adolescent Health, (Add Health; mean = 16.4 years, 52.6% female), we assessed the interaction of ST (h week<sup>−1</sup>) and 41 established obesity single nucleotide polymorphisms (SNPs) with age‐ and sex‐specific BMI Z‐scores in 4788 European–American (EA), 1612 African–American (AA) and 1242 Hispanic American (HA) adolescents.</p> </sec> <sec id="ijpo195-sec-0004" sec-type="section"> <title>Results</title> <p>Nominally significant SNP*ST interaction were found for <italic>FL</italic>J35779 in EA, <italic>GNPDA2</italic> in AA and none in HA (EA: beta [SE] = 0.016[0.007]), AA: beta [SE] = 0.016[0.011]) per 7 h week<sup>−1</sup> ST and one risk allele in relation to BMI Z‐score.</p> </sec> <sec id="ijpo195-sec-0005" sec-type="section"> <title>Conclusions</title> <p>While for two established BMI loci, we find evidence that high levels of ST exacerbate the influence of obesity susceptibility variants on body mass; overall, we do not find strong evidence for interactions between the majority of established obesity loci. However, future studies with larger sample sizes, or that may build on our current study and the growing published literature, are clearly warranted.</p> </sec> </abstract>