Reliable chemical exchange saturation transfer imaging of human lumbar intervertebral discs using reduced‐field‐of‐view turbo spin echo at 3.0 T. (25th July 2013)

• Record Type: Journal Article
• Authors: Liu, Qi; Jin, Ning; Fan, Zhaoyang; Natsuaki, Yutaka; Tawackoli, Wafa; Pelled, Gadi; Bae, Hyun; Gazit, Dan; Li, Debiao
• Is Part Of: NMR in biomedicine. Volume 26:Number 12(2013:Dec.)
• Page Start: 1672
• Page End: 1679
• Publication Date: 2013-07-25
• Subjects: Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.3001
• Languages: English
• ISSNs: 0952-3480

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The reduced field‐of‐view (rFOV) turbo‐spin‐echo (TSE) technique, which effectively suppresses bowel movement artifacts, is developed for the purpose of chemical exchange saturation transfer (CEST) imaging of the intervertebral disc (IVD) <italic>in vivo</italic>. Attempts to quantify IVD CEST signals in a clinical setting require high reliability and accuracy, which is often compromised in the conventionally used technique. The proposed rFOV TSE CEST method demonstrated significantly superior reproducibility when compared with the conventional technique on healthy volunteers, implying it is a more reliable measurement. Phantom study revealed a linear relation between CEST signal and glycosaminoglycan (GAG) concentration. The feasibility of detecting IVD degeneration was demonstrated on a healthy volunteer, indicating that the proposed method is a promising tool to quantify disc degeneration. Copyright © 2013 John Wiley &amp; Sons, Ltd.</p> </abstract>