Orlistat improves endothelial function in obese adolescents: A randomised trial. Issue 11 (5th June 2013)

• Record Type: Journal Article
• Authors: Yu, Clare CW; Li, Albert M; Chan, Karly OW; Chook, Ping; Kam, Jack TC; Au, Chun T; So, Raymond CH; Sung, Rita YT; McManus, Alison M
• Is Part Of: Journal of paediatrics and child health. Volume 49:Issue 11(2013:Nov.)
• Page Start: 969
• Page End: 975
• Publication Date: 2013-06-05
• Subjects: Children -- Health and hygiene -- Periodicals; Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/jpc.12252
• Languages: English
• ISSNs: 1034-4810

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jpc12252-sec-0001" sec-type="section"> <title>Aim</title> <p>To investigate the effect of orlistat on endothelial function in obese adolescents.</p> </sec> <sec id="jpc12252-sec-0002" sec-type="section"> <title>Methods</title> <p>Single‐blind 10‐week controlled trial of 67 normolipidaemic obese adolescents randomised into three groups. Group 1 (diet alone), Group 2 (diet and orlistat), Group 3 (diet, orlistat and exercise). Endothelial function measured by flow‐mediated dilatation (FMD) of the brachial artery, anthropometric parameters, blood pressure, fasting blood lipids, insulin and glucose levels were recorded at baseline and at 10 weeks.</p> </sec> <sec id="jpc12252-sec-0003" sec-type="section"> <title>Results</title> <p>Sixty four subjects completed the study. Groups were comparable at baseline. FMD increased significantly with orlistat (Groups 2 and 3) but not in Group 1. Orlistat treatment resulted in significantly reduced bodyweight, body mass index (BMI), waist circumference, total and low‐density lipoprotein (LDL) cholesterol levels. High‐density lipoprotein cholesterol levels were unchanged. Triglyceride and insulin levels were significantly reduced in all three groups. The reduction in cholesterols did not correlate with reductions in weight and BMI. A slight reduction of body fat, both with and without orlistat treatment, correlated with reduction in BMI after adjustment for baseline values. Blood pressure was unaltered by orlistat. Calorie intake was reduced with orlistat, and the decrease noted in % fat and increase in % carbohydrate was significant only in those taking orlistat. The addition of exercise (Group 3 compared with Group 2) altered no parameter.</p> </sec> <sec id="jpc12252-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Orlistat improves endothelial function and reduces bodyweight, BMI, fasting total and LDL‐cholesterol in obese adolescents when combined with dietary control. Improvement in endothelial function if maintained could reflect long‐term cardiovascular benefit.</p> </sec> </abstract>