Association of the tumour necrosis factor‐α polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta‐analysis. (December 2013)

• Record Type: Journal Article
• Authors: Jia, Y.; Qin, H. J.; Zhang, J. X.; Liu, X. L.; Li, L. J.
• Is Part Of: Clinical and experimental dermatology. Volume 38:Number 8(2013)
• Page Start: 836
• Page End: 844
• Publication Date: 2013-12
• Subjects: Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/ced.12136
• Languages: English
• ISSNs: 0307-6938

Abstract

<abstract abstract-type="main" id="ced12136-abs-0001"> <title>Summary</title> <sec id="ced12136-sec-0001" sec-type="section"> <title>Background</title> <p>Evidence has suggested that tumour necrosis factor (TNF)‐α may be involved in the aetiology of psoriasis, but the underlying association of the TNF‐α polymorphisms −238G/A (rs361525) and −308G/A (rs1800629) with the risk of psoriasis is still unconfirmed.</p> </sec> <sec id="ced12136-sec-0002" sec-type="section"> <title>Aim</title> <p>This meta‐analysis was performed to determine whether the TNF‐α −238G/A and −308G/A polymorphisms are associated with susceptibility to psoriasis.</p> </sec> <sec id="ced12136-sec-0003" sec-type="section"> <title>Methods</title> <p>Eligible studies were identified by searching PubMed, EMBASE, CNKI (China National Knowledge Infrastructure), CBM (Chinese biomedical literature database) and WANFANG databases within a range of published years from 1990 to August 2012. The odds ratio (OR) and 95% confidence interval (CI) were used to assess the different associations.</p> </sec> <sec id="ced12136-sec-0004" sec-type="section"> <title>Results</title> <p>In total, 17 studies with 2847 cases and 2222 controls were found for −238G/A and 20 studies with 2975 cases and 2243 controls for −308G/A. The pooled results showed an overall increased risk of psoriasis for the −238G/A polymorphism (OR = 2.06, 95% CI = 1.45–2.94, <italic>P </italic>< 0.001 for AA/GA vs. GG) and a reduced psoriasis risk with the −308G/A polymorphism (OR = 0.68, 95% CI = 0.59–0.79, <italic>P </italic>< 0.001 for AA/GA vs. GG). This association was only present in early‐onset psoriasis (OR = 3.68, 95% CI = 2.17–6.24, <italic>P </italic>< 0.001 for −238G/A; OR = 0.56, 95% CI = 0.43–0.72, <italic>P </italic>< 0.001 for −308G/A), whereas there was no association (OR = 0.98, 95% CI = 0.56–1.70, <italic>P = </italic>0.92 for −238G/A) or a unreliable association (OR = 0.66, 95% CI = 0.46–0.94, <italic>P = </italic>0.02 for −308G/A) in late‐onset psoriasis.</p> </sec> <sec id="ced12136-sec-0005" sec-type="section"> <title>Conclusions</title> <p>This meta‐analysis suggests that the TNF‐α –238 and –308 promoter polymorphisms may play different roles in conferring susceptibility to psoriasis. Functional and well‐designed studies should be conducted to confirm these results.</p> </sec> </abstract>