Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: The breast cancer health disparities study. Issue 3 (9th August 2013)

• Record Type: Journal Article
• Authors: Slattery, Martha L.; John, Esther M.; Torres‐Mejia, Gabriela; Lundgreen, Abbie; Lewinger, Juan Pablo; Stern, Mariana C.; Hines, Lisa; Baumgartner, Kathy B.; Giuliano, Anna R.; Wolff, Roger K.
• Is Part Of: International journal of cancer. Volume 134:Issue 3(2014:Feb. 01)
• Page Start: 629
• Page End: 644
• Publication Date: 2013-08-09
• Subjects: Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.28377
• Languages: English
• ISSNs: 0020-7136

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Angiogenesis is essential for tumor development and progression. Genetic variation in angiogenesis‐related genes may influence breast carcinogenesis. We evaluated dietary factors associated with oxidative balance, <italic>DDIT4</italic> (one SNP), <italic>FLT1</italic> (35 SNPs), <italic>HIF1A</italic> (four SNPs), <italic>KDR</italic> (19 SNPs), <italic>MPO</italic> (one SNP), <italic>NOS2A</italic> (15 SNPs), <italic>TEK</italic> (40 SNPs) and <italic>VEGFA</italic> (eight SNPs) and breast cancer risk among Hispanic (2, 111 cases and 2, 597 controls) and non‐Hispanic white (1, 481 cases and 1, 586 controls) women in the Breast Cancer Health Disparities Study. Adaptive rank truncated product (ARTP) analysis was used to determine gene and pathway significance with breast cancer. <italic>TEK</italic> was associated with breast cancer overall (<italic>p</italic><sub>ARTP</sub> = 0.03) and with breast cancer survival (<italic>p</italic><sub>ARTP</sub> = 0.01). <italic>KDR</italic> was of borderline significance overall (<italic>p</italic><sub>ARTP</sub> = 0.07), although significantly associated with breast cancer in both low and intermediate Native American (NA) ancestry groups (<italic>p</italic><sub>ARTP</sub> = 0.02) and estrogen receptor (ER)+/progesterone receptor (PR)− tumor phenotype (<italic>p</italic><sub>ARTP</sub> = 0.008). Both <italic>VEGFA</italic> and <italic>NOS2A</italic> were associated with ER−/PR− tumor phenotype (<italic>p</italic><sub>ARTP</sub> = 0.01 and <italic>p</italic><sub>ARTP</sub> = 0.04, respectively). <italic>FLT1</italic> was associated with breast cancer survival among those with low NA ancestry (<italic>p</italic><sub>ARTP</sub> = 0.009). With respect to diet, having a higher dietary oxidative balance score (DOBS) was significantly associated with lower breast cancer risk [odds ratio (OR) 0.74, 95% confidence interval (CI) 0.64–0.84], with the strongest associations observed for women with the highest NA ancestry (OR 0.44, 95% CI 0.30–0.65). We observed few interactions between DOBS and angiogenesis‐related genes. Our data suggest that dietary factors and genetic variation in angiogenesis‐related genes contribute to breast cancer carcinogenesis.</p> </abstract>