Usefulness of plasma B-type natriuretic peptide as a prognostic marker of cardiac function in senile systemic amyloidosis and in familial amyloidotic polyneuropathy. (December 2013)

• Record Type: Journal Article
• Authors: Usuku, Hiroki; Obayashi, Konen; Shono, Makoto; Oshima, Toshinori; Tasaki, Masayoshi; Yasuda, Hisayo; Ogawa, Hisao; Ando, Yukio
• Is Part Of: Amyloid. Volume 20:Number 4(2013:Dec.)
• Page Start: 251
• Page End: 255
• Publication Date: 2013-12
• Subjects: Amyloidosis -- Periodicals; 616.3995
• DOI: 10.3109/13506129.2013.844122
• Languages: English
• ISSNs: 1350-6129

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: In senile systemic amyloidosis (SSA), a common age-related amyloidosis, wild-type transthyretin accumulates in tissues, with a primary result being cardiac dysfunction. Here, we aimed to clarify the usefulness of B-type natriuretic peptide (BNP) as a prognostic marker of cardiac function in SSA and in familial amyloidotic polyneuropathy (FAP).</p> <p> <italic>Methods and results</italic>: We studied 13 patients with severe SSA and 14 patients with FAP. SSA patients, but not FAP patients, demonstrated a significant correlation of log BNP with the echocardiographic diastolic marker <italic>E</italic>/<italic>e</italic>′ ratio (<italic>r</italic> = 0.78, <italic>p</italic> < 0.01). SSA patients also showed significant correlations between log BNP and log C-reactive protein or log high-sensitive troponin T (<italic>r</italic> = 0.70, <italic>p</italic> < 0.01; <italic>r</italic> = 0.64, <italic>p</italic> < 0.05). FAP patients, however, had significant correlations between log BNP and left ventricular wall thickness (intraventricular septum thickness diastole and posterior wall thickness diastole) (<italic>r</italic> = 0.73, <italic>p</italic> < 0.01; <italic>r</italic> = 0.77, <italic>p</italic> < 0.01). The mean log BNP level in the follow-up period was significantly higher than that in the diagnostic period in SSA patients (2.65 ± 0.45 versus 2.36 ± 0.40, <italic>p</italic> < 0.01) but not in FAP patients (1.91 ± 0.56 versus 1.93 ± 0.45, <italic>p</italic> = 0.87). An especially notable phenomenon was the high plasma BNP level (≥180 pg/ml) in SSA patients.</p> <p> <italic>Conclusion</italic>: Plasma BNP levels may be a useful prognostic marker of cardiac function in SSA.</p> </abstract>