Type II diabetes mellitus and menopause: a multinational study. (December 2013)

• Record Type: Journal Article
• Authors: Monterrosa-Castro, A.; Blümel, J. E.; Portela-Buelvas, K.; Mezones-Holguín, E.; Barón, G.; Bencosme, A.; Benítez, Z.; Bravo, L. M.; Calle, A.; Chedraui, P.; Flores, D.; Espinoza, M. T.; Gómez, G.; Hernández-Bueno, J. A.; Laribezcoa, F.; Lima, S.; Martino, M.; Mostajo, D.; Ojeda, E.; Onatra, W.; Sánchez, H.; Navarro, D.; Tserotas, K.; Vallejo, M. S.; Witis, S.; Zuñiga, M. C.
• Is Part Of: Climacteric. Volume 16:Number 6(2013:Dec.)
• Page Start: 663
• Page End: 672
• Publication Date: 2013-12
• Subjects: Menopause -- Periodicals; Menopause -- Hormone therapy -- Periodicals; Menopause -- Periodicals; Estrogen Replacement Therapy -- Periodicals; Gynecology -- Periodicals; Societies, Medical -- Periodicals; 612.665
• DOI: 10.3109/13697137.2013.798272
• Languages: English
• ISSNs: 1369-7137

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background</italic> Type II diabetes mellitus causes metabolic changes that may lead to early menopause and worsen climacteric symptoms.</p> <p> <italic>Objectives</italic> To determine the risk factors for type II diabetes mellitus and assess the impact of this disease on the age of menopause and on climacteric symptoms.</p> <p> <italic>Methods</italic> A total of 6079 women aged between 40 and 59 years from 11 Latin American countries were requested to answer the Menopause Rating Scale and Goldberg Anxiety-Depression Scale.</p> <p> <italic>Results</italic> The prevalence of diabetes was 6.7%. Diabetes mellitus was associated with arterial hypertension (odds ratio (OR) 4.49; 95% confidence interval (CI) 3.47–5.31), the use of psychotropic drugs (OR 1.54; 95% CI 1.22–1.94), hormonal therapy (OR 1.46; 95% CI 1.11–1.92), ≥ 50 years of age (OR 1.48; 95% CI 1.17–1.86), overweight or obese (OR 1.47; 95% CI 1.15–1.89), and waist circumference ≥ 88 cm (OR 1.32; 95% CI 1.06–1.65). Factors associated with lower risk of diabetes were the use of hormonal contraceptives (OR 0.55; 95% CI 0.35–0.87), alcohol (OR 0.73; 95% CI 0.54–0.98) and living in cities > 2500 meters above sea level (OR 0.70; 95% CI 0.53–0.91) or with high temperatures (OR 0.67; 95% CI 0.51–0.88). In turn, diabetes tripled the risk of menopause in women under 45 years of age. Diabetes did not increase the risk of deterioration of quality of life due to climacteric symptoms.</p> <p> <italic>Conclusion</italic> Menopause does not increase the risk of type II diabetes mellitus. Diabetes is associated with early menopause in women under 45 years of age.</p> </abstract>