High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards. (December 2013)

• Record Type: Journal Article
• Authors: Slaughter, Jaime; Wei, Changshuai; Korzeniewski, Steven J.; Lu, Qing; Beck, John S.; Khoo, Sok Kean; Brovont, Ariel; Maurer, Joel; Martin, Denny; Lenski, Madeleine; Paneth, Nigel
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 26:Number 18(2013)
• Page Start: 1765
• Page End: 1767
• Publication Date: 2013-12
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2013.804050
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective:</italic> To examine the correlation in genes expressed in paired umbilical cord blood (UCB) and newborn blood (NB).</p> <p> <italic>Method:</italic> Total mRNA and mRNA of three gene sets (inflammatory, hypoxia, and thyroidal response) was assessed using microarray in UCB and NB spotted on Guthrie cards from 7 mother/infant pairs.</p> <p> <italic>Results:</italic> The average gene expression correlation between paired UCB and NB samples was 0.941 when all expressed genes were considered, and 0.949 for three selected gene sets.</p> <p> <italic>Conclusion:</italic> The high correlation of UCB and NB gene expression suggest that either source may be useful for examining gene expression in the perinatal period.</p> </abstract>