Does transient hypothyroxinemia influence metabolic bone disease of prematurity?. (December 2013)

• Record Type: Journal Article
• Authors: Demirel, Utku; Özek, Eren; Bereket, Abdullah; Demirel, Bilge; Topuzoğlu, Ahmet; Akman, İpek
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 26:Number 18(2013)
• Page Start: 1844
• Page End: 1849
• Publication Date: 2013-12
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2013.804051
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP).</p> <p> <italic>Method</italic>: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age ≤34 weeks, were enrolled. Clinical features were recorded. Serum TSH, free T₄, total T₄, calcium, phosphorus and total Alkaline Phosphatase (ALP) levels were determined in the first and third postnatal weeks. MBD was defined as a phosphorus level &lt;4.5 mg/dl and/or ALP &gt;900 IU/l. THOP was defined as a serum free and/or total thyroxine level lower than −1 SD for gestational age at the 7th postnatal day.</p> <p> <italic>Result</italic>: THOP was diagnosed in nineteen (15.3%) patients. MBD was diagnosed in 52 (41.9%) at the 3rd month. Low birth weight, low gestational age and prolonged parenteral nutrition were associated with MBD. Multivariate analysis documented a significant relationship solely between MBD and gestational age.</p> <p> <italic>Conclusion</italic>: The risk of MBD does not increase significantly in babies with THOP.</p> </abstract>