Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population. (November 2013)

• Record Type: Journal Article
• Authors: Qiu, R; Zhang, H; Zhao, H; Li, J; Guo, C; Gong, Y; Liu, Q
• Is Part Of: Scandinavian journal of rheumatology. Volume 42:Number 6(2013)
• Page Start: 469
• Page End: 472
• Publication Date: 2013-11
• Subjects: Rheumatology -- Periodicals; Arthritis; Rheumatic Diseases; 616.72005
• DOI: 10.3109/03009742.2013.786755
• Languages: English
• ISSNs: 0300-9742

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Objectives:</bold> The aim of this study was to test whether orosomucoid like 3 (<italic>ORMDL3</italic>) and 17q21 variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population.</p> <p> <bold>Method:</bold> A total of 753 unrelated AS patients and 1120 ethnically matched healthy controls were recruited. Seven single nucleotide polymorphisms (SNPs: rs7216389, rs12603332, rs12936231, rs9303277, rs11557467, rs1007654, and rs17608925), which were selected from chromosome 17q21 containing the genes <italic>ORMDL3</italic>, <italic>GSDMB</italic>, <italic>ZPBP2</italic>, and <italic>IKZF3</italic>, were genotyped by the Taqman SNP genotyping assay.</p> <p> <bold>Results:</bold> Five of the SNPs (rs7216389, rs12603332, rs12936231, rs9303277, and rs11557467) were associated with AS (all p ≤ 0.01), especially in males (all p &lt; 0.001). Of these, rs7216389, rs12603332, rs12936231, and rs11557467 were strongly associated with severity of the disease based on radiographic findings (p &lt; 0.05).</p> <p> <bold>Conclusions:</bold> Our study confirmed that variants in chromosome 17q21 are significantly associated with AS in a Chinese Han population.</p> </abstract>