Prospective evaluation of term neonate brain damage following preceding hypoxic sentinel events using enhanced T2* weighted angiography (eSWAN). (1st December 2013)

• Record Type: Journal Article
• Authors: Ling, Xueying; Huang, Li; Liu, Guosheng; Tang, Wen; Li, Xiaofei; Li, Bingxiao; Wu, Hejia; Liu, Sirun
• Is Part Of: International journal of neuroscience. Volume 123:Number 12(2013:Dec.)
• Page Start: 837
• Page End: 846
• Publication Date: 2013-12-01
• Subjects: Nervous system -- Periodicals; 612.805
• DOI: 10.3109/00207454.2013.804820
• Languages: English
• ISSNs: 0020-7454

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Purpose</italic>: To evaluate the brain damage of term neonates with evidence of a preceding hypoxic sentinel event using eSWAN prospectively. <italic>Methods</italic>: The study was approved by the institutional research ethics committee. Among the neonates who were examined during the first 8 days after birth with conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and eSWAN, 39 neonates with a preceding acute hypoxic sentinel event were divided into two groups: the hypoxic ischaemic encephalopathy (HIE) group and the high-risk group. Twenty-five neonates were normal control subjects. Conventional MRI, DWI, and T<sub>2</sub>* and R<sub>2</sub>* maps from eSWAN were assessed. T<sub>2</sub>* and R<sub>2</sub>* values from T<sub>2</sub>* and R<sub>2</sub>* maps were calculated in predefined regions in the HIE and high-risk groups and then compared with those in control subjects. <italic>Results</italic>: The neonates in the HIE and high-risk groups showed a high percentage of cerebral oedema and periventricular white-matter (PWM) lesions. Cerebral oedema and haemorrhagic lesions of PWM were more highly visible on the T<sub>2</sub>* map compared with conventional MRI: cerebral oedema was illustrated as a high T<sub>2</sub>* area and haemorrhagic lesions had a significantly lower T<sub>2</sub>* on the T<sub>2</sub>* map. Lower R<sub>2</sub>* values of lentiform nuclei (LN) and a higher T<sub>2</sub>* and lower R<sub>2</sub>* of frontal white matter (FWM) were found in neonates in the HIE group relative to those of normal controls. The T<sub>2</sub>* value of LN in the high-risk group was higher than that of the normal controls. <italic>Conclusions</italic>: The T<sub>2</sub>* map from eSWAN is useful in detecting cerebral oedema and haemorrhagic lesions of PWM in neonates. The measurement of T<sub>2</sub>* and R<sub>2</sub>* values is helpful in assessing the LN and FWM damage in neonates following a hypoxic sentinel event.</p> </abstract>