Effects of a Sustained‐Release Form of Isosorbide Dinitrate on Left Atrial Pressure in Dogs with Experimentally Induced Mitral Valve Regurgitation. (6th September 2013)

• Record Type: Journal Article
• Authors: Yamamoto, Y.; Suzuki, S.; Hamabe, L.; Aytemiz, D.; Huai‐Che, H.; Kim, S.; Yoshiyuki, R.; Fukayama, T.; Fukushima, R.; Tanaka, R.
• Is Part Of: Journal of veterinary internal medicine. Volume 27:Number 6(2013:Nov./Dec.)
• Page Start: 1421
• Page End: 1426
• Publication Date: 2013-09-06
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12184
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12184-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12184-sec-0001" sec-type="section"> <title>Background</title> <p>The effects of isosorbide dinitrate (ISDN) have not been sufficiently investigated in conscious dogs with mitral valve regurgitation (MR).</p> </sec> <sec id="jvim12184-sec-0002" sec-type="section"> <title>Objective</title> <p>The objective was to investigate the effects of a sustained‐release form of ISDN (sr‐ISDN) on hemodynamics and the autonomic nervous system in dogs with MR.</p> </sec> <sec id="jvim12184-sec-0003" sec-type="section"> <title>Animals</title> <p>Six healthy Beagles weighing 11.2 ± 2.2 kg (2 years of age; 2 males and 4 females) were used.</p> </sec> <sec id="jvim12184-sec-0004" sec-type="section"> <title>Methods</title> <p>Experimental, crossover, and interventional study. Dogs with experimentally induced MR were administered placebo, 2, 5, and 10 mg/kg sr‐ISDN PO on separate days with a 7‐day washout period between randomized dosings. Left atrial pressure (LAP) had been recorded continuously from 30 minutes before administration of sr‐ISDN to 12 hours after administration.</p> </sec> <sec id="jvim12184-sec-0005" sec-type="section"> <title>Results</title> <p>LAP was significantly decreased after administration in the 5 and 10 mg/kg groups. Significant decrease was observed at 3 and 4 hours after administration in the 5 mg/kg group. In the 10 mg/kg group, significant decrease was observed at 2, 3, 4, 5, 6, 7, 10, and 11 hours after administration. The lowest value was observed at 4 hours after administration in the 5 and 10 mg/kg groups (20.9 ± 4.2 to 15.9 ± 3.9 mmHg, <italic>P</italic> < .01, and 21.3 ± 4.0 to 13.6 ± 4.2 mmHg, <italic>P</italic> < .001).</p> </sec> <sec id="jvim12184-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>Sustained‐release form of ISDN showed significant decrease of LAP in the 5 mg/kg and 10 mg/kg groups, and duration of effect was dose related.</p> </sec> </abstract>