Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice. (5th August 2013)

• Record Type: Journal Article
• Authors: Du, Jing; Liang, Yu; Xu, Feng; Sun, Bing; Wang, Zhao
• Is Part Of: Journal of pharmacy and pharmacology. Volume 65:Number 12(2013:Dec.)
• Page Start: 1753
• Page End: 1756
• Publication Date: 2013-08-05
• Subjects: Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12108
• Languages: English
• ISSNs: 0022-3573

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jphp12108-sec-1001" sec-type="section"> <title>Objective</title> <p>Alzheimer's Disease (AD) is well characterized by the accumulated Aβ plaque in hippocampus and cerebral cortex concomitant with markedly reduced study and learning ability. Trehalose, a natural disaccharide, has been shown to have neural protective properties and exhibited therapeutic effects in animal models of several neural degenerative disorders. However, the effect of trehalose on AD pathology remains largely unknown.</p> </sec> <sec id="jphp12108-sec-1002" sec-type="section"> <title>Methods</title> <p>In this study, we evaluated the effects of trehalose in APP/PS1 transgenic mice through behaviour tests and biochemical analyses.</p> </sec> <sec id="jphp12108-sec-1003" sec-type="section"> <title>Key findings</title> <p>We found that the impaired cognitive and learning ability was improved and Aβ deposit in hippocampus was reduced.</p> </sec> <sec id="jphp12108-sec-1004" sec-type="section"> <title>Conclusions</title> <p>These results suggested that trehalose could be a potential therapeutic drug for the treatment of AD.</p> </sec> </abstract>