Trilostane Therapy for Treatment of Spontaneous Hyperadrenocorticism in Cats: 15 Cases (2004–2012). (6th September 2013)

• Record Type: Journal Article
• Authors: Mellett Keith, A.M.; Bruyette, D.; Stanley, S.
• Is Part Of: Journal of veterinary internal medicine. Volume 27:Number 6(2013:Nov./Dec.)
• Page Start: 1471
• Page End: 1477
• Publication Date: 2013-09-06
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12178
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12178-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12178-sec-0001" sec-type="section"> <title>Background</title> <p>Medical treatment with trilostane improves clinical signs, causes unclear insulin requirement changes, and variable survival times in cats.</p> </sec> <sec id="jvim12178-sec-0002" sec-type="section"> <title>Objectives/Hypothesis</title> <p>To characterize the long‐term efficacy of trilostane in treating cats with hyperadrenocorticism (HAC).</p> </sec> <sec id="jvim12178-sec-0003" sec-type="section"> <title>Animals</title> <p>Fifteen client‐owned cats with spontaneous HAC.</p> </sec> <sec id="jvim12178-sec-0004" sec-type="section"> <title>Methods</title> <p>Multicenter descriptive retrospective study with a search performed on all medical records for cats diagnosed with spontaneous HAC.</p> </sec> <sec id="jvim12178-sec-0005" sec-type="section"> <title>Results</title> <p>Clinical signs (13 of 15 cats) and ACTH stimulation testing results (13 of 15) improved with trilostane therapy. Diabetes mellitus was reported in 9/15 cases. Insulin requirements decreased by 36% within 2 months in 6/9 diabetic cats. Median survival time was 617 days for all cats (range 80–1, 278 days). Complications included weight loss, urinary tract infections, chronic kidney disease, seizures, and recurrent pancreatitis. Hypocortisolemia was documented in 1 case. Cause of death occurred as a result of nonadrenal or nondiabetic illnesses (renal failure, seizures [caused by hypoglycemia or unknown]), or lymphoma.</p> </sec> <sec id="jvim12178-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>Trilostane ameliorates clinical signs of HAC in cats, is tolerated well in the long term, and can lead to improved regulation of diabetes.</p> </sec> </abstract>