Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice. Issue 6 (24th December 2012)

• Record Type: Journal Article
• Authors: Sanders, Robert D.; Godlee, Alexandra; Goulding, John C.; Ma, Daqing; Maze, Mervyn; Hussell, Tracy
• Is Part Of: Influenza and other respiratory viruses. Volume 7:Issue 6(2013:Nov.)
• Page Start: 895
• Page End: 899
• Publication Date: 2012-12-24
• Subjects: Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12066
• Languages: English
• ISSNs: 1750-2640

Abstract

<abstract abstract-type="main" xml:lang="en" id="irv12066-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Animal models of viral respiratory disease often use weight loss as a marker of disease severity; however, this may relate to dehydration and malnutrition that would be corrected clinically. We tested whether parenteral fluid therapy improved weight loss from influenza infection. BALB/c and C57BL/6 mice were infected with A/X31 (H3N2) influenza and randomized to intraperitoneal fluid therapy. Blood glucose was also measured post‐viral infection on day 3 and 6 in BALB/c mice and on day 6 in C57BL/6 mice. Parenteral fluids did not alter weight loss or the immunological response to infection, and glucose levels were not abnormal.</p> </abstract>