Evaluation of death pathway genes FAS and FASL polymorphisms in chronic HBV infection. (7th April 2013)

• Record Type: Journal Article
• Authors: Zamani, A. G.; Barlas, I. O.; Durakbasi‐Dursun, G.; Ural, O.; Erdal, E.; Yildirim, M. S.
• Is Part Of: International journal of immunogenetics. Volume 40:Number 6(2013:Dec.)
• Page Start: 482
• Page End: 487
• Publication Date: 2013-04-07
• Subjects: Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12056
• Languages: English
• ISSNs: 1744-3121

Abstract

<abstract abstract-type="main" id="iji12056-abs-0001"> <title>Summary</title> <sec id="iji12056-sec-0001" sec-type="section"> <p>This study was designed to determine the possible asssociation between selected <italic>FAS</italic> and <italic>FASLG</italic> polymorphisms and Hepatitis B virus (HBV) infection. <italic>FAS</italic>‐670 G/A, <italic>FAS</italic>‐1377 G/A, <italic>FASLG</italic>‐844 T/C and <italic>FASLG</italic> IVS2nt‐124 A/G polymorphisms were genotyped by polymerase chain reaction and restriction fragment length polymorphism (PCR‐RFLP). A total of age and sex matched 108 controls and a hundred chronic HBV patients were recruited to conduct a case–control study. <italic>FAS</italic>‐670 polymorphism was associated with chronic HBV infection (<italic>P</italic> = 0.03) <italic>FAS‐</italic>1377 GG, GA and AA genotypes among the cases (90%, 5% and 5%, respectively) were significantly different from those among the controls (68%, 31.5% and 5.6%; <italic>P</italic> = 0.00). <italic>FASLG</italic>‐844 allele distribution was similar between the groups (<italic>P</italic> = 0.17) but TC genotype (67.3%) was frequent in chronic HBV patients, while CC genotype was found significantly higher (29.6%) in controls. No association between <italic>FASLG</italic> IVS2nt‐124 polymorphism and chronic HBV infection could be identified (<italic>P</italic> = 0.55). <italic>FAS</italic>‐670 polymorphism is associated with chronic HBV infection, while <italic>FASLG</italic> IVS2nt‐124 A/G polymorphism is not. The <italic>FAS</italic>‐1377G/A and <italic>FASLG‐</italic>844 T/C genotypes are likely to play a substantial role in HBV infection. Further studies evaluating polymorphisms in other genes related with apoptosis are needed to elucidate the role of genetic variation in HBV infection.</p> </sec> </abstract>