Cutting Edge: IL‐10‐Producing Regulatory B Cells in Early Human Pregnancy. (10th October 2013)

• Record Type: Journal Article
• Authors: Rolle, Luise; Memarzadeh Tehran, Maryam; Morell‐García, Anselm; Raeva, Yanitsa; Schumacher, Anne; Hartig, Roland; Costa, Serban‐Dan; Jensen, Federico; Zenclussen, Ana Claudia
• Is Part Of: American journal of reproductive immunology. Volume 70:Number 6(2013:Dec.)
• Page Start: 448
• Page End: 453
• Publication Date: 2013-10-10
• Subjects: Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12157
• Languages: English
• ISSNs: 1046-7408

Abstract

<abstract abstract-type="main" id="aji12157-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="aji12157-sec-0001" sec-type="section"> <title>Problem</title> <p>The function of IL‐10 producing regulatory B cells (Breg) during gestation is unknown. Here, we aimed to understand their participation in early pregnancy.</p> </sec> <sec id="aji12157-sec-0002" sec-type="section"> <title>Method</title> <p>CD19⁺CD24^hiCD27⁺B cell frequency, measured by flow cytometry, increased with pregnancy onset but not in the case of spontaneous abortions.</p> </sec> <sec id="aji12157-sec-0003" sec-type="section"> <title>Results</title> <p>B cells from non‐pregnant women cultured with serum from normal pregnant women produced higher IL‐10 levels than those cultured with serum from spontaneous abortion patients or autologous serum. CD19⁺‐activated B cells from pregnant women strongly suppressed TNF‐a production by CD4⁺T cells when cocultured. We identified hCG as an important factor regulating the number and function of Breg during pregnancy.</p> </sec> <sec id="aji12157-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Breg emerge as important players in pregnancy; they suppress undesired immune responses from maternal T cells and are therefore important for tolerance acquisition.</p> </sec> </abstract>