Clinical inertia in the treatment of hyperglycemia in type 2 diabetes patients in primary care. (November 2013)

• Record Type: Journal Article
• Authors: Mata-Cases, Manel; Benito-Badorrey, Belén; Roura-Olmeda, Pilar; Franch-Nadal, Josep; Pepió-Vilaubí, Josep Maria; Saez, Marc; Coll-de-Tuero, Gabriel
• Is Part Of: Current medical research and opinion. Volume 29:Number 11(2013:Nov.)
• Page Start: 1495
• Page End: 1502
• Publication Date: 2013-11
• Subjects: Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1185/03007995.2013.833089
• Languages: English
• ISSNs: 0300-7995

Abstract

<abstract> <title>Abstract</title> <sec id="ss1"> <title>Objective:</title> <p>To assess clinical inertia, defined as failure to intensify antidiabetic treatment of patients who have not achieved the HbA<sub>1c</sub> therapeutic goal (≤7%).</p> </sec> <sec id="ss2"> <title>Research design and methods:</title> <p>Multicenter cross-sectional study. Clinical inertia was assessed in a random sample of type 2 diabetes mellitus (T2DM) patients seen in primary care centers.</p> </sec> <sec id="ss3"> <title>Results:</title> <p>A total of 2783 patients (51.3% males; mean age: 68 [±11.5] years; diabetes duration: 7.1 [±5.6] years; mean HbA<sub>1c</sub>: 6.8 [±1.5]) were analyzed. Of those, 997 (35.8%) had HbA<sub>1c</sub> >7%. Treatment was intensified in 66.8% and consisted of: dose increase (40.5%); addition of oral antidiabetic (45.8%); or insulin treatment initiation (3.7%). Mean HbA<sub>1c</sub> values in patients for whom treatment was intensified vs. non-intensified were 8.4% (±1.2) vs. 8.2% (±1.2), <italic>p</italic> < 0.05. Clinical inertia was detected in 33.2% of patients and diminished along with treatment complexity: lifestyle changes only (38.8%), oral monotherapy (40.3%), combined oral antidiabetics (34.5%), insulin monotherapy (26.1%) and combination of insulin and oral antidiabetics (21.4%). Clinical inertia decreased as HbA<sub>1c</sub> increased: 37.3% for HbA<sub>1c</sub> values ranging between 7.1%–8%; 29.4% for the 8.1%–9% HbA<sub>1c</sub> range and 27.1% for HbA<sub>1c</sub> ≥9%. Multivariate analysis confirmed that diabetes duration, step of treatment and HbA<sub>1c</sub> were related to inertia. For each unit of HbA<sub>1c</sub> increase clinical inertia decreased 47% (OR: 0.53).</p> </sec> <sec id="ss4"> <title>Limitations:</title> <p>The retrospective design of the study precluded an accurate investigation about reasons for lack of intensification that could actually be justified by some patient conditions, especially patients' lack of adherence.</p> </sec> <sec id="ss5"> <title>Conclusions:</title> <p>Clinical inertia affected one third of T2DM patients with poor glycemic control and was greater in patients treated with only lifestyle changes or oral monotherapy. Treatment changes were performed when mean HbA<sub>1c</sub> values were 1.4 points above therapeutic goals.</p> </sec> </abstract>