Associations between CD14 −159 C>T polymorphism and chronic/aggressive periodontitis susceptibility. (21st March 2013)

• Record Type: Journal Article
• Authors: Zhang, H; Zhou, l; Han, Y; Cai, Q; Li, D; Pan, Y; Wang, L
• Is Part Of: Oral diseases. Volume 19:Number 8(2013:Nov.)
• Page Start: 805
• Page End: 811
• Publication Date: 2013-03-21
• Subjects: Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12096
• Languages: English
• ISSNs: 1354-523X

Abstract

<abstract abstract-type="main" id="odi12096-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="odi12096-sec-0001" sec-type="section"> <title>Objectives</title> <p> <italic>CD14</italic> is a causative gene for periodontitis. However, conflicting results had been achieved when evaluating the associations between <italic>CD14</italic> −159 C>T and periodontitis, which warranted us to conduct this meta‐analysis.</p> </sec> <sec id="odi12096-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>A meta‐analysis based on eight relevant case–control studies was conducted to address this issue. Odds ratios (OR) with 95% confidence intervals (CIs) were applied to test the association. The statistical heterogeneity across studies was assessed by Chi‐square‐based <italic>Q</italic>‐test.</p> </sec> <sec id="odi12096-sec-0003" sec-type="section"> <title>Results</title> <p>Retrieved studies regarding <italic>CD14</italic> −159 C>T and periodontitis susceptibility were put into the final analysis. Overall and subgroup analyses were performed. Finally, we did not find that this polymorphism could contribute to modified risk of periodontitis or in stratified analysis by ethnicity and type of disease. However, this polymorphism was associated with decreased risk of mild to moderate periodontitis (TT <italic>vs </italic>CC, OR = 0.42, 95% CI = 0.21–0.81, CT/CC <italic>vs </italic>TT, OR = 1.91, 95% CI = 1.09–3.35) but not severe periodontitis.</p> </sec> <sec id="odi12096-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The present meta‐analysis provided confirmative evidence that <italic>CD14</italic> −159 C>T was involved in the development of periodontitis.</p> </sec> </abstract>