Prevalence of non classical congenital adrenal hyperplasia due to 21‐hydroxylase deficiency in Greek women with acne: a hospital‐based cross‐sectional study. (15th June 2012)

• Record Type: Journal Article
• Authors: Trakakis, E.; Papadavid, E.; Dalamaga, M.; Koumaki, D; Stavrianeas, N.; Rigopoulos, D.; Creatsas, G.; Kassanos, D.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 27:Number 11(2013:Nov.)
• Page Start: 1448
• Page End: 1451
• Publication Date: 2012-06-15
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/j.1468-3083.2012.04613.x
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p> <bold>Aim </bold> To determine the prevalence and frequency of non classical congenital adrenal hyperplasia (NC‐CAH) due to 21‐OHD at the time of clinical presentation and at the peripubertal period in a substantial sample of Greek women with acne and to investigate the correlation of serum T, 17‐OHP and DHEA‐S with acne appearance at the time of clinical presentation.</p> <p> <bold>Methods </bold> One hundred and twenty‐three unselected women with hyperandrogenemic symptoms were examined. After the ACTH stimulation test, 6 (4.9%) women were diagnosed with NC‐CAH due to 21‐OHD.</p> <p> <bold>Results </bold> There was not any statistical significant difference in the frequency of peripubertal acne between NC‐CAH group of patients (6.4%) and patients with hyperandrogenemia of other aetiology (93%), mainly ovarian (<italic>P </italic>= 0.41). However, there was a statistical significant difference in the prevalence of acne at the time of clinical examination between the two groups (<italic>P </italic>= 0.04). Acne was present in 83.3% of women with NC‐CAH vs. 41.02% of women in the hyperandrogenic group without NC‐CAH. A statistically significant decrease of acne from the peripubertal time to the time of clinical examination in the group of women with hyperandrogenemia of other aetiology (−21.37%) was observed compared to women with NC‐CAH (<italic>P </italic>< 0.001).</p> <p> <bold>Conclusion </bold> We have shown that acne persists from peripubertal period to adult life in NC‐CAH women whereas it tends to diminish in women with hyperandrogenemia of other aetiology. Acne is a prominent finding in women with NC‐CAH. Serum concentrations of 17‐OHP after ACTH stimulation (17‐OHP<sub>6O</sub>) should be investigated in women with persistent acne in adult life.</p> </abstract>