Unravelling the molecular complexity of GPCR‐mediated EGFR transactivation using functional genomics approaches. (23rd September 2013)

• Record Type: Journal Article
• Authors: George, Amee J.; Hannan, Ross D.; Thomas, Walter G.
• Is Part Of: FEBS journal. Volume 280:Number 21(2013)
• Page Start: 5258
• Page End: 5268
• Publication Date: 2013-09-23
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.12509
• Languages: English
• ISSNs: 1742-464X

Abstract

<abstract abstract-type="main" id="febs12509-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>To influence physiology and pathophysiology, G protein‐coupled receptors (GPCRs) have evolved to appropriate additional signalling modalities, such as activation of adjacent membrane receptors. Epidermal growth factor receptors (EGFRs) mediate growth and remodelling actions of GPCRs, although the precise network of gene products and molecular cascades linking GPCRs to EGFRs (termed EGFR transactivation) remains incomplete. In this review, we describe the current view of GPCR–EGFR transactivation, identifying the established models of receptor cross‐talk. We consider the limitations in our current knowledge, and propose that recent advances in molecular and cell biology technology, including functional genomics approaches, will allow a renewed focus of efforts to understand the mechanism underlying EGFR transactivation. Using an unbiased approach for identification of the molecules required for GPCR‐mediated EGFR transactivation will provide a contemporary and more complete representation from which to extrapolate therapeutic control in diseases from cardiovascular remodelling to cancer.</p> </abstract>