Large IncHI2‐plasmids encode extended‐spectrum β‐lactamases (ESBLs) in Enterobacter spp. bloodstream isolates, and support ESBL‐transfer to Escherichia coli. (25th June 2013)

• Record Type: Journal Article
• Authors: Nilsen, E.; Haldorsen, B. C.; Sundsfjord, A.; Simonsen, G. S.; Ingebretsen, A.; Naseer, U.; Samuelsen, Ø.; Cantón, R.
• Is Part Of: Clinical microbiology and infection. Volume 19:Number 11(2013:Nov.)
• Page Start: E516
• Page End: E518
• Publication Date: 2013-06-25
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/1469-0691.12274
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" id="clm12274-abs-0001"> <title>Abstract</title> <p>We investigated the prevalence of extended‐spectrum β‐lactamases (ESBLs) in <italic>Enterobacter</italic> spp. bloodstream isolates from 19 hospital laboratories in Norway during 2011. A total of 62/230 (27%) isolates were resistant to third‐generation cephalosporins and four (1.7%) were ESBL‐positive; <italic>bla</italic>_CTX_‐M‐15 (<italic>n</italic> = 3) and <italic>bla</italic>_SHV_‐12 (<italic>n</italic> = 1). This is comparable to the prevalence of ESBLs in clinical isolates of <italic>Escherichia coli</italic> and <italic>Klebsiella pneumoniae</italic> in Norway during the same period. All ESBL‐positive isolates were multidrug resistant (MDR) and harboured plasmid‐mediated quinolone resistance. Three isolates supported transfer of large IncHI2‐plasmids harbouring ESBL‐ and MDR‐encoding genes to <italic>E. coli</italic> recipients by <italic>in vitro</italic> conjugation.</p> </abstract>