Evaluation of methoxy polyethylene glycol‐polylactide diblock copolymers as additive in hypromellose film coating. (16th September 2013)

• Record Type: Journal Article
• Authors: Cespi, Marco; Casettari, Luca; Bonacucina, Giulia; Giorgioni, Gianfabio; Perinelli, Diego R; Palmieri, Giovanni Filippo
• Is Part Of: Polymers for advanced technologies. Volume 24:Number 11(2013:Nov.)
• Page Start: 1018
• Page End: 1024
• Publication Date: 2013-09-16
• Subjects: Polymers -- Periodicals; 668.9
• DOI: 10.1002/pat.3182
• Languages: English
• ISSNs: 1042-7147

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>This paper deals with a new application of diblock methoxy polyethylene glycol‐polylactide block copolymers, a class of synthetic biomaterials largely studied in the pharmaceutical and biomedical fields owing to their favorable properties such as biocompatibility, biodegradability, low immunogenicity, and good mechanical properties.</p> <p>In this work, these materials were evaluated as additives for gastro‐soluble pharmaceutical coating aimed to reduce film stiffness and water permeability. Two copolymers with different polylactide chain lengths were synthesized and characterized in term of molecular weight and solid‐state properties. A series of free films with different hypromellose/copolymers ratio were prepared and characterized in terms of appearance, components miscibility, plasticity, and water vapor permeability.</p> <p>The obtained results demonstrate that copolymers effectively influence hypromellose film properties according to their concentration and molecular weight. Specifically, the addition of the copolymer with a molecular weight of 6.5 kDa in a ratio hypromellose:polymer 5:1, allowed to obtain films with good appearance, improved plasticization, and water permeability properties. For higher molecular weight, copolymer or different ratios was not possible to observe the improvement of all the properties at the same time. The results also make possible to define the critical features to improve in order to use block copolymers as additive in hypromellose film coating.</p> <p>The availability of new water‐soluble additives able to work as plasticizer and moisture sealer in polymeric films represents an important progress not only in the field of pharmaceutical coating but also in that of food coatings, as for example in the formulation of edible films. Copyright © 2013 John Wiley & Sons, Ltd.</p> </abstract>