Influence of a collagen membrane and recombinant platelet‐derived growth factor on vertical bone augmentation in implant‐fixed deproteinized bovine bone – animal pilot study. Issue 11 (4th July 2012)

• Record Type: Journal Article
• Authors: Kämmerer, P.W.; Palarie, V.; Schiegnitz, E.; Nacu, V.; Draenert, F.G.; Al‐Nawas, B.
• Is Part Of: Clinical oral implants research. Volume 24:Issue 11(2013:Nov.)
• Page Start: 1222
• Page End: 1230
• Publication Date: 2012-07-04
• Subjects: Dental implants -- Research -- Periodicals; 617.69
• DOI: 10.1111/j.1600-0501.2012.02534.x
• Languages: English
• ISSNs: 0905-7161

Abstract

<abstract abstract-type="main" id="clr2534-abs-0001"> <title>Abstract</title> <sec id="clr2534-sec-0001" sec-type="section"> <title>Objectives</title> <p>Combinations of bone substitute block materials with membrane techniques as well as with growth factors are possible options to enhance the prognosis of vertical bone augmentation. Therefore, the aim of the pilot study was to compare the influence of a collagen membrane and a signal protein (rhPDGF‐BB) on vertical bone augmentation with a stable fixed block material (deproteinized bovine bone [DBB]).</p> </sec> <sec id="clr2534-sec-0002" sec-type="section"> <title>Materials and methods</title> <p>In 12 rabbits, a DBB‐block was implant‐fixed on the tibia in a split‐leg‐design. Included were: DBB only (control), DBB + collagen membrane (test), DBB + rhPDGF‐BB (test) and DBB + rhPDGF‐BB + collagen membrane (test). 24 samples were examined after 3 (<italic>n</italic> = 12) and 6 weeks (<italic>n</italic> = 12). Calculated parameters were new bone area (NBA;%), new vertical bone height (VBH; mm). Due to the pilot character of this study, single values are shown descriptively only.</p> </sec> <sec id="clr2534-sec-0003" sec-type="section"> <title>Results</title> <p>After 3 weeks, there were constant higher NBA values in the rhPDGF‐BB‐group without membrane (NBA (%) DBB: 30/16/4; DBB + membrane: 25/17/7, DBB + rhPDGF‐BB: 40/33/34, DBB + rhPDGF‐BB + membrane: 0/30/16; VBH (mm) DBB: 1.2/1.2/1, DBB + membrane: 0.7/0.9/1, DBB + rhPDGF‐BB: 0.7/0.9/1, DBB + rhPDGF‐BB + membrane: 0/1.1/1). After 6 weeks, both membrane groups showed a constant higher NBA and VBH independent to the use of rhPDGF‐BB (NBA DBB: 3/0/5, DBB + membrane: 20/35/31, DBB + rhPDGF‐BB: 5/8/4, DBB + rhPDGF‐BB + membrane: 31/35/40; VBH DBB: 0.3/0.3/0.6, DBB + membrane: 1.6/2.4/2.1, DBB + rhPDGF‐BB: 0.4/0.7/0.8, DBB + rhPDGF‐BB + membrane: 1.8/2/1.8).</p> </sec> <sec id="clr2534-sec-0004" sec-type="section"> <title>Conclusions</title> <p>For vertical augmentation, the addition of rhPDGF‐BB to DBB‐blocks may increase early bone growth. In the later phase, the use of a collagen membrane enhances new bone volume and height to a significant greater extend. Even if the results are higher than those in the non‐membrane groups, the low gain of bone after the short time periods still needs improvement.</p> </sec> </abstract>