Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system. Issue Volume 20:Issue11(2013:Nov.) (7th January 2013)

• Record Type: Journal Article
• Authors: Banati, M.; Csecsei, P.; Koszegi, E.; Nielsen, H. H.; Suto, G.; Bors, L.; Trauninger, A.; Csepany, T.; Rozsa, C.; Jakab, G.; Molnar, T.; Berthele, A.; Kalluri, S. R.; Berki, T.; Illes, Z.
• Is Part Of: European journal of neurology. Volume 20:Issue11(2013:Nov.)
• Page Start: 1492
• Page End: 1495
• Publication Date: 2013-01-07
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12072
• Languages: English
• ISSNs: 1351-5101

Abstract

<abstract abstract-type="main" xml:lang="en" id="ene12072-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ene12072-sec-0001" sec-type="section"> <title>Background</title> <p>Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and CNS autoimmunity.</p> </sec> <sec id="ene12072-sec-0002" sec-type="section"> <title>Methods</title> <p>Antibodies against gliadin, tissue transglutaminase (tTG), intrinsic factor (IF), parietal cells (PC) and <italic>Saccharomyces cerevisiae</italic> (ASCA) were screened in the sera of 45 patients with AQP4‐seropositive neuromyelitis optica (NMO) and NMO spectrum diseases (NMO/NMO‐SD), 17 patients with AQP4‐seronegative NMO, 85 patients with clinically definite multiple sclerosis (MS), and 48 healthy controls (HC).</p> </sec> <sec id="ene12072-sec-0003" sec-type="section"> <title>Results</title> <p>Thirty‐seven percentages of patients with AQP4‐seropositive NMO/NMO‐SD and 28% of patients with MS had at least one particular antibody in contrast to 8% of HC (<italic>P</italic> < 0.01, respectively). Antibodies were most common (46%) in AQP4‐seropositive myelitis (<italic>P</italic> = 0.01 versus HS, <italic> P</italic> = 0.05 versus MS). Anti‐gliadin and ASCA were more frequent in the AQP4‐seropositive NMO‐spectrum compared to controls (<italic>P</italic> = 0.01 and <italic>P</italic> < 0.05, respectively).</p> </sec> <sec id="ene12072-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Antibody responses against gastrointestinal antigens are common in MS and AQP4‐seropositive NMO/NMO‐SD, especially in longitudinally extensive myelitis.</p> </sec> </abstract>