Diabetes incidence does not differ between subjects with and without high depressive symptoms — 5‐year follow‐up results of the Heinz Nixdorf Recall Study. Issue 1 (13th December 2012)

• Record Type: Journal Article
• Authors: Icks, A.; Albers, B.; Haastert, B.; Pechlivanis, S.; Bokhof, B.; Slomiany, U.; Erbel, R.; Jöckel, K.‐H.; Kruse, J.; Nowotny, B.; Herder, C.; Giani, G.; Moebus, S.
• Is Part Of: Diabetic medicine. Volume 30:Issue 1(2013:Jan.)
• Page Start: 65
• Page End: 69
• Publication Date: 2012-12-13
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/j.1464-5491.2012.03724.x
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="sec-sum-1" sec-type="section"> <p>Diabet. Med. 30, 65–69 (2013)</p> </sec> <sec id="abs1-1" sec-type="section"> <title>Abstract</title> <p> <bold>Aims </bold> Cross‐sectional studies <italic>have</italic> consistently reported evidence for an association between diabetes and depressive disorders. However, only limited prospective studies <italic>have</italic> examined this association, reporting conflicting results. In a population‐based cohort study, we compared cumulative incidences of diabetes between participants with and without high depressive symptoms.</p> <p> <bold>Method </bold> We analy<italic>s</italic>ed the 5‐year follow‐up data from the German Heinz Nixdorf Recall study of 3547 participants without diabetes at baseline <italic>[</italic>mean age 58.8 (<sc>sd</sc><italic> </italic>7.6) years, 47.5% male<italic>].</italic> Depressive symptoms were defined using the Centr<italic>e</italic> for Epidemiologic Studies Depression scale (cut point <italic>≥ </italic>17). Diabetes (diagnosed or previously undetected) was identified by self‐reported physician‐diagnosed diabetes, medication and high blood glucose levels. We estimated 5‐year cumulative incidences with 95% confidence intervals and fitted multiple logistic regression models to calculate the odds ratios, adjusted for age, sex, physical activity, smoking, living with or without partner, and educational level.</p> <p> <bold>Results </bold> The cumulative incidence of diabetes was 9.2% (95%<italic> CI</italic> 6.3<italic>–</italic>12.8) in participants with high depressive symptoms at baseline and 9.0% (<italic>95% CI</italic> 8.0<italic>–</italic>10.0) in participants without these symptoms. The age‐ and sex‐adjusted <italic>odds ratio</italic> of diabetes in participants with depressive symptoms compared <italic>with</italic> those without was 1.13 <italic>[95% CI</italic> 0.77<italic>–</italic>1.68; fully adjusted 1.11 (<italic>95% CI</italic> 0.74<italic>–</italic>1.65)<italic>].</italic> These results did not substantially change in several additional sensitivity analyses.</p> <p> <bold>Conclusion </bold> Our study did not show a significantly increased risk of developing diabetes in individuals with high depressive symptoms compared <italic>with</italic> those without high depressive symptoms during a <italic>5‐</italic>year follow‐up period.</p> </sec> </abstract>