Single-walled carbon nanotubes mediated targeted tamoxifen delivery system using aspargine-glycine-arginine peptide. (November 2013)

• Record Type: Journal Article
• Authors: Chen, Chengqun; Hou, Lin; Zhang, Huijuan; Zhu, Ling; Zhang, Hongling; Zhang, Chaofeng; Shi, Jinjin; Wang, Lei; Jia, Xin; Zhang, Zhenzhong
• Is Part Of: Journal of drug targeting. Volume 21:Number 9(2013)
• Page Start: 809
• Page End: 821
• Publication Date: 2013-11
• Subjects: Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.3109/1061186X.2013.829071
• Languages: English
• ISSNs: 1061-186X

Abstract

<abstract> <title>Abstract</title> <p>An aspargine-glycine-arginine (NGR) peptide modified single-walled carbon nanotubes (SWCNTs) system, developed by a simple non-covalent approach, could be loaded with the anticancer drug tamoxifen (TAM). This TAM-loaded NGR modified SWCNTs (TAM/NGR-SWCNTs) not only retained both optical properties of SWCNTs and cytotoxicity of TAM, but also could accumulate in tumors and enter into 4T1 cells, which facilitated combination chemotherapy with photothermal therapy in one targeting system. Enhanced cellular uptake, antitumor effect and cell apoptosis of TAM/NGR-SWCNTs on 4T1 cells were observed <italic>in vitro</italic>, compared with the TAM solution, TAM/SWCNTs and photothermal therapy alone. <italic>In vivo</italic> investigation of TAM/NGR-SWCNTs in tumor-bearing mice further confirmed that this system possessed much higher tumor targeting capacity and antitumor efficacy than the control, especially with the near-infrared-laser irradiation treatment. Moreover, it demonstrated negligible systematic toxicity through the histopathological analysis. All these results suggest TAM/NGR-SWCNTs are promising for high targeted efficiency and treatment efficacy and low side effects of future cancer therapy by synergistic effect of chemo-photothermal combination.</p> </abstract>