Apoptosis through regulation of Bcl-2, Bax and Mcl-1 expressions in endometriotic cyst lesions and the endometrium of women with moderate to severe endometriosis. (October 2013)

• Record Type: Journal Article
• Authors: Korkmaz, D.; Bastu, E.; Dural, O.; Yasa, C.; Yavuz, E.; Buyru, F.
• Is Part Of: Journal of obstetrics and gynaecology. Volume 33:Number 7(2013)
• Page Start: 725
• Page End: 728
• Publication Date: 2013-10
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618.05
• DOI: 10.3109/01443615.2013.824416
• Languages: English
• ISSNs: 0144-3615

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>The aim of the study was to evaluate apoptosis through regulation of Bcl-2, Bax and Mcl-1 proteins by comparing their expressions in endometriotic cyst lesions and the endometrium of the patients with moderate to severe endometriosis. This is a cross-sectional study of 30 women in reproductive age with a clinical or sonographic suspicion of endometrioma, who underwent laparoscopy. Bcl-2 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly reduced in the cystic endometriotic lesions (<italic>p < </italic>0.0001). There was a significant difference in Bcl-2 expression between cystic endometriotic stromal cells and endometrial stromal cells (<italic>p < </italic>0.0001). Bax expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the endometrium (<italic>p < </italic>0.0001). There was a significant difference in Bax expression between cystic endometriotic stromal cells and endometrial stromal cells (<italic>p</italic> = 0.03). Mcl-1 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the cystic endometriotic lesions (<italic>p</italic> = 0.003). Apoptosis may play a role in the pathophysiology of endometriosis by potentially contributing to the survival of regurgitating endometrial cells in the peritoneal cavity.</p> </abstract>