Effect of dexmedetomidine on plasma brain-derived neurotrophic factor: A double-blind, randomized and placebo-controlled study. (November 2013)

• Record Type: Journal Article
• Authors: Yang, Lin; Xu, Jun-Mei; Jiang, XingHua; Ruan, Wei; Cui, YuLong; He, Liang
• Is Part Of: Upsala journal of medical sciences. Volume 118:Number 4(2013:Dec.)
• Page Start: 235
• Page End: 239
• Publication Date: 2013-11
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Electronic journals; 610.5
• DOI: 10.3109/03009734.2013.808295
• Languages: English
• ISSNs: 0300-9734

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background.</italic> Dexmedetomidine (DEX) has neuro-protective effects, but the clinical mechanism remains unclear.</p> <p> <italic>Method.</italic> Forty patients were randomly divided into two groups: group A (control) and group B (treated with DEX). Plasma concentrations of brain-derived neurotrophic factor (BDNF) were determined in blood samples using enzyme-linked immunosorbent assays at five time points: T1 (baseline), T2 (15 minutes after intubation and before the surgery was started), T3 (the end of surgery), T4 (10 minutes after extubation in the post-anesthesia care unit), and T5 (24 hours after the surgery). Changes in bispect (BIS) index, heart rates, and doses of anesthetics used for induction were also recorded.</p> <p> <italic>Results.</italic> Baseline plasma concentrations of BDNF did not differ between group A and group B; 15 minutes after induction, concentrations of plasma BDNF were significantly reduced in group A. Twenty-four hours after surgery, the concentration was still higher in group B than in group A. In contrast, plasma concentrations of BDNF at other time points tested did not differ between the two groups.</p> <p> <italic>Conclusion.</italic> It appears that DEX could reverse the reduced plasma concentrations of BDNF caused by anesthetics, and this effect lasted for 24 hours after surgery.</p> </abstract>