Association between KCNQ1 genetic variants and QT interval in a Chinese population. Issue 10 (21st June 2013)

• Record Type: Journal Article
• Authors: Yu, W.; Zhang, F.; Hu, W.; Zhang, R.; Wang, C.; Lu, J.; Jiang, F.; Tang, S.; Peng, D.; Chen, M.; Bao, Y.; Xiang, K.; Hu, C.; Jia, W.
• Is Part Of: Diabetic medicine. Volume 30:Issue 10(2013:Oct.)
• Page Start: 1225
• Page End: 1229
• Publication Date: 2013-06-21
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12237
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12237-abs-0001"> <title>Abstract</title> <sec id="dme12237-sec-0001" sec-type="section"> <title>Aim</title> <p>There is a close link between electrocardiographic ventricular repolarization QT parameters and Type 2 diabetes. The aim of the present study was to assess the effects of QT‐related and diabetes‐related variants in <italic>KCNQ1</italic> on QT interval in a Chinese population.</p> </sec> <sec id="dme12237-sec-0002" sec-type="section"> <title>Methods</title> <p>We recruited 2415 patients with Type 2 diabetes and 1163 subjects with normal glucose regulation in the present study. QT interval was obtained and the heart rate‐corrected QT interval (QTc) was calculated using Bazett's formula. Four single nucleotide polymorphisms in <italic>KCNQ1</italic> were selected (rs12296050, rs12576239, rs2237892 and rs2237895) and genotyped.</p> </sec> <sec id="dme12237-sec-0003" sec-type="section"> <title>Results</title> <p> In participants with normal glucose regulation, the minor allele T of rs12296050 was associated with a 3.46‐ms QTc prolongation under an additive model (<italic>P</italic> = 0.0109, empirical <italic>P</italic> <italic>=</italic> 0.0498). In patients with Type 2 diabetes, we did not find any association for the single nucleotide polymorphisms.</p> </sec> <sec id="dme12237-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our findings indicate that <italic>KCNQ1</italic> is associated with QT interval in a Chinese population with normal glucose regulation.</p> </sec> </abstract>