Effects of Piperine, Cinnamic Acid and Gallic Acid on Rosuvastatin Pharmacokinetics in Rats. (3rd December 2012)

• Record Type: Journal Article
• Authors: Basu, Sudipta; Jana, Snehasis; Patel, Vandana B.; Patel, Hitesh
• Is Part Of: Phytotherapy research. Volume 27:Number 10(2013:Oct.)
• Page Start: 1548
• Page End: 1556
• Publication Date: 2012-12-03
• Subjects: Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.4894
• Languages: English
• ISSNs: 0951-418X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The purpose of this study was to investigate the potential pharmacokinetic interactions with natural products (such as piperine (PIP), gallic acid (GA) and cinnamic acid (CA)) and rosuvastatin (RSV) (a specific breast cancer resistance protein, BCRP substrate) in rats. In Caco₂ cells, the polarized transport of RSV was effectively inhibited by PIP, CA and GA at concentration of 50 μM. After per oral (p.o.) coadministration of PIP, CA and GA (10 mg/kg) significantly increased intravenous exposure (AUC_last) of RSV (1 mg/kg) by 73.5%, 62.9% and 53.3% (<italic>p</italic> &lt; 0.05), respectively than alone group (control). Compared with the control (alone) group, p.o. coadministration of PIP, CA and GA (10 mg/kg) significantly increased the oral exposure (AUC_last) of RSV (5 mg/kg) by 2.0‐fold, 1.83‐fold (<italic>p</italic> &lt; 0.05) and 2.34 ‐fold (<italic>p</italic> &lt; 0.05), respectively. Moreover, the cumulative biliary excretion of RSV (5 mg/kg, p.o.) was significantly decreased by 53.3, 33.4 and 39.2% at the end of 8 h after p.o. co‐administration of PIP, CA and GA (10 mg/kg), respectively. Taken together, these results indicate that the natural products such as PIP, CA and GA significantly inhibit RSV transport in to bile and increased the plasma exposure (AUC_last) of RSV. Copyright © 2012 John Wiley &amp; Sons, Ltd.</p> </abstract>