Toll‐deficient Drosophila is susceptible to Pythium insidiosum infection. (13th October 2013)

• Record Type: Journal Article
• Authors: Zanette, Régis A.; Santurio, Janio M.; Loreto, Érico S.; Alves, Sydney H.; Kontoyiannis, Dimitrios P.
• Is Part Of: Microbiology and immunology. Volume 57:Number 10(2013:Oct.)
• Page Start: 732
• Page End: 735
• Publication Date: 2013-10-13
• Subjects: Microbiology -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Microbiologie -- Périodiques; Immunologie -- Périodiques; 579
• DOI: 10.1111/1348-0421.12082
• Languages: English
• ISSNs: 0385-5600

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>ABSTRACT</title> <sec id="mim12082-sec-0001" sec-type="section"> <p>There is a paucity of animal models of pythiosis, a life‐threatening disease of humans and animals, the immunopathogenesis of which is poorly understood. A pythiosis model was developed by injecting <italic>Toll</italic> (<italic>Tl</italic>)‐deficient <italic>Drosophila melanogaster</italic> flies with <italic>Pythium insidiosum</italic> zoospores. The infected <italic>Tl</italic> mutant flies had significantly lower survival rates (73.7%) than did control flies. This study reveals the important role of <italic>Tl</italic> pathway activation in fly immune response to pythiosis.</p> </sec> </abstract>