Adipocytokines levels at delivery, functional variation of TFAP2β, and maternal and neonatal anthropometric parameters. (29th May 2013)

• Record Type: Journal Article
• Authors: Comasco, Erika; Iliadis, Stavros I.; Larsson, Anders; Olovsson, Matts; Oreland, Lars; Sundström‐Poromaa, Inger; Skalkidou, Alkistis
• Is Part Of: Obesity. Volume 21:Number 10(2013:Oct.)
• Page Start: 2130
• Page End: 2137
• Publication Date: 2013-05-29
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20349
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20349-sec-0001" sec-type="section"> <title>Objective</title> <p>Adipocytokines participate in the regulation of glucose metabolism and fetal development. The transcription factor activating protein 2B (TFAP2β) has been associated with adipocytokine regulation, and gene variations with type 2 diabetes and obesity. This study investigated associations between maternal <italic>TFAP2B</italic> variation, adipocytokine levels, and maternal and neonatal anthropometric characteristics.</p> </sec> <sec id="oby20349-sec-0002" sec-type="section"> <title>Design and Methods</title> <p>A population‐based sample of women was followed from delivery to 6 months postpartum. Adiponectin, leptin, and interleukin‐6 levels at delivery, and maternal as well as neonatal anthropometric variables were assessed. The <italic>TFAP2β</italic> intron 1 variable number tandem repeat (VNTR) was genotyped.</p> </sec> <sec id="oby20349-sec-0003" sec-type="section"> <title>Results</title> <p>Maternal interleukin‐6 correlated positively with leptin at delivery, with peripartum weight changes and weight of newborn males, adjusted for potential confounders. Leptin at delivery was associated with <italic>TFAP2β</italic> intron 1 VNTR genotype, adjusted for confounders, maternal weight and negatively with birth weight among female neonates. A path model suggested a link between <italic>TFAP2β</italic> genotype, leptin levels, and newborn females' weight.</p> </sec> <sec id="oby20349-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The present results stress a role for the <italic>TFAP2 β</italic> in adiposity‐related conditions and intrauterine growth. The association between neonatal birth weight and maternal adipocytokine levels, together with the observed sex effect, call for further studies on the mechanisms behind neuroendocrine fetal programming.</p> </sec> </abstract>