Dyslipidemia links obesity to early cerebral neurochemical alterations. (25th May 2013)

• Record Type: Journal Article
• Authors: Haley, Andreana P.; Gonzales, Mitzi M.; Tarumi, Takashi; Tanaka, Hirofumi
• Is Part Of: Obesity. Volume 21:Number 10(2013:Oct.)
• Page Start: 2007
• Page End: 2013
• Publication Date: 2013-05-25
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20332
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20332-sec-0001" sec-type="section"> <title>Objective</title> <p>To examine the role of hypertension, hyperglycemia, and dyslipidemia in potentially accounting for obesity‐related brain vulnerability in the form of altered cerebral neurochemistry.</p> </sec> <sec id="oby20332-sec-0002" sec-type="section"> <title>Design and Methods</title> <p>Sixty‐four adults, ages 40‐60 years, underwent a health screen and proton magnetic resonance spectroscopy (<sup>1</sup>H MRS) of occipitoparietal gray matter to measure <italic>N</italic>‐acetyl aspartate (NAA), choline (Cho), <italic>myo</italic>‐inositol (mI), and glutamate (Glu) relative to creatine (Cr). The causal steps approach and nonparametric bootstrapping were utilized to assess if fasting glucose, mean arterial pressure or peripheral lipid/lipoprotein levels mediate the relationship between body mass index (BMI) and cerebral neurochemistry.</p> </sec> <sec id="oby20332-sec-0003" sec-type="section"> <title>Results</title> <p>Higher BMI was significantly related to higher mI/Cr, independent of age and sex. BMI was also significantly related to two of the proposed mediators, triglyceride, and HDL‐cholesterol, which were also independently related to increased mI/Cr. Finally, the relationship between BMI and mI/Cr was significantly attenuated after inclusion of triglyceride and HDL‐cholesterol into the model, one at a time, indicating statistical mediation.</p> </sec> <sec id="oby20332-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Higher triglyceride and lower HDL levels statistically account for the association between BMI and <italic>myo</italic>‐inositol, pointing toward a potentially critical role for dyslipidemia in the development of cerebral neurochemical alterations in obesity.</p> </sec> </abstract>