Early‐pregnancy maternal vitamin D status and maternal hyperglycaemia. Issue 9 (13th June 2013)

• Record Type: Journal Article
• Authors: Tomedi, L. E.; Simhan, H. N.; Bodnar, L. M.
• Is Part Of: Diabetic medicine. Volume 30:Issue 9(2013:Sep.)
• Page Start: 1033
• Page End: 1039
• Publication Date: 2013-06-13
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12229
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12229-abs-0001"> <title>Abstract</title> <sec id="dme12229-sec-0001" sec-type="section"> <title>Aims</title> <p>To estimate the association between serum 25‐hydroxyvitamin D concentrations and maternal hyperglycaemia (post‐load glucose concentration ≥ 7.5 mmol/l).</p> </sec> <sec id="dme12229-sec-0002" sec-type="section"> <title>Methods</title> <p>Pregnant women (<italic>n </italic>=<italic> </italic>429; 61% black, 36% obese, 45% smokers) enrolled in a cohort study at <16 weeks gestation. Non‐fasting blood samples were assayed for serum 25‐hydroxyvitamin D at enrolment. At 24–28 weeks gestation, maternal hyperglycaemia was determined using a 50‐g 1‐h oral glucose challenge test.</p> </sec> <sec id="dme12229-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 67% of women had 25‐hydroxyvitamin D concentrations < 50 nmol/l and 11% had maternal hyperglycaemia. Among smokers, each 23‐nmol/l increase in serum 25‐hydroxyvitamin D was associated with a reduction in the odds of maternal hyperglycaemia [odds ratio: 0.30 (95% CI: 0.13, 0.68)] after adjustment for parity, race/ethnicity, age, pre‐pregnancy BMI, marital status, income, family history of diabetes, and gestational age of gestational diabetes mellitus screening. Among non‐smokers, we found no association between early pregnancy vitamin D status and maternal hyperglycaemia.</p> </sec> <sec id="dme12229-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Smoking status may modify the relationship between poor maternal vitamin D status and maternal hyperglycaemia.</p> </sec> </abstract>