Vitamin D levels during and after resolution of ketoacidosis in children with new onset Type 1 diabetes. Issue 7 (21st May 2013)

• Record Type: Journal Article
• Authors: Devidayal, ; Singh, M. K.; Sachdeva, N.; Singhi, S.; Attri, S. V.; Jayashree, M.; Bhalla, A. K.
• Is Part Of: Diabetic medicine. Volume 30:Issue 7(2013:Jul.)
• Page Start: 829
• Page End: 834
• Publication Date: 2013-05-21
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12200
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12200-abs-0001"> <title>Abstract</title> <sec id="dme12200-sec-0001" sec-type="section"> <title>Aim</title> <p>To study the effect of ketoacidosis on measured 25‐hydroxyvitamin D3 in children with new onset Type 1 diabetes.</p> </sec> <sec id="dme12200-sec-0002" sec-type="section"> <title>Methods</title> <p>Measurement of pH and bicarbonate levels was carried out in children with newly diagnosed Type 1 diabetes at presentation with ketoacidosis. 25‐hydroxyvitamin D3 estimation was carried out at presentation (timepoint 1) and 1 month later (timepoint 2). There was no significant difference in the mean (±<sc>sd</sc>) 25‐hydroxyvitamin D3 levels [35.39 (±25.79) vs 39.63 (±48.03) nmol/L; <italic>P </italic>=<italic> </italic>0.661) at the two timepoints in the study.</p> </sec> <sec id="dme12200-sec-0003" sec-type="section"> <title>Results</title> <p>Correlation analysis revealed a positive correlation between bicarbonate levels and timepoint 1, i.e. the lower the bicarbonate levels, the lower were the timepoint 1 levels and vice versa (correlation coefficient 0.538, <italic>P </italic>=<italic> </italic>0.001). Timepoint 2 levels also showed a positive correlation with serum bicarbonate levels with a correlation coefficient of 0.379 (<italic>P </italic>=<italic> </italic>0.032). None of the variables other than bicarbonate, .(age, gender, BMI, pH or time), was found to have the predictive ability for timepoint1 levels. Similarly for predicting timepoint 2 levels, BMI was found to have independent predictive ability in addition to bicarbonate.</p> </sec> <sec id="dme12200-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Severe ketoacidosis, as judged by bicarbonate but not pH, may transiently lower 25‐hydroxyvitamin D3 levels in children with new onset Type 1 diabetes. Persistence of low 25‐hydroxyvitamin D3 levels after resolution of ketoacidosis suggests a state of permanent vitamin D deficiency in our patient population.</p> </sec> </abstract>