Association of HLA‐G 3′ untranslated region polymorphisms with antibody response against Plasmodium falciparum antigens: preliminary results. Issue 1 (10th June 2013)

• Record Type: Journal Article
• Authors: Sabbagh, A.; Courtin, D.; Milet, J.; Massaro, J. D.; Castelli, E. C.; Migot‐Nabias, F.; Favier, B.; Rouas‐Freiss, N.; Moreau, P.; Garcia, A.; Donadi, E. A.
• Is Part Of: Tissue antigens. Volume 82:Issue 1(2013)
• Page Start: 53
• Page End: 58
• Publication Date: 2013-06-10
• Subjects: Antigens -- Periodicals; Immunological tolerance -- Periodicals; Immunogenetics -- Periodicals; 571.9645
• DOI: 10.1111/tan.12140
• Languages: English
• ISSNs: 0001-2815

Abstract

<abstract abstract-type="main" id="tan12140-abs-0001"> <title>Abstract</title> <p id="tan12140-para-0001">Host and <italic>Plasmodium</italic> interactions result in highly variable clinical phenotypes, partly explained by the nature and level of anti‐malarial antibody response. Human leukocyte antigen (HLA)‐G can create a tolerogenic environment, allowing parasites to escape from anti‐malarial immunity. We performed a family‐based association study encompassing 483 Sereer individuals (261 children and their parents), and reported two independent signals at the <italic>HLA‐G</italic> 3′ untranslated region associated with antibody response to specific <italic>Plasmodium falciparum</italic> blood stage antigens, previously associated with malaria protection: (i) +3010G together with +3142C with total IgG and IgG1 against GLURP and (ii) +3196G with IgG3 against MSP2. While these results require further investigation, they suggest for the first time a role of <italic>HLA‐G</italic> in the regulation of humoral immune response in malaria.</p> </abstract>