Haptoglobin phenotype, pre‐eclampsia, and response to supplementation with vitamins C and E in pregnant women with type‐1 diabetes. Issue 10 (30th May 2013)

• Record Type: Journal Article
• Authors: Weissgerber, TL; Gandley, RE; Roberts, JM; Patterson, CC; Holmes, VA; Young, IS; McCance, DR
• Is Part Of: BJOG. Volume 120:Issue 10(2013:Oct.)
• Page Start: 1192
• Page End: 1199
• Publication Date: 2013-05-30
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.12288
• Languages: English
• ISSNs: 1470-0328

Abstract

<abstract abstract-type="main" id="bjo12288-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bjo12288-sec-0001" sec-type="section"> <title>Objective</title> <p>The phenotype of the antioxidant and pro‐angiogenic protein haptoglobin (Hp) predicts cardiovascular disease risk and treatment response to antioxidant vitamins in individuals with diabetes. Our objective was to determine whether Hp phenotype influences pre‐eclampsia risk, or the efficacy of vitamins C and E in preventing pre‐eclampsia, in women with type‐1 diabetes.</p> </sec> <sec id="bjo12288-sec-0002" sec-type="section"> <title>Design</title> <p>This is a secondary analysis of a randomised controlled trial in which women with diabetes received daily vitamins C and E, or placebo, from 8 to 22 weeks of gestation until delivery.</p> </sec> <sec id="bjo12288-sec-0003" sec-type="section"> <title>Setting</title> <p>Twenty‐five antenatal metabolic clinics across the UK (in north‐west England, Scotland, and Northern Ireland).</p> </sec> <sec id="bjo12288-sec-0004" sec-type="section"> <title>Population</title> <p>Pregnant women with type‐1 diabetes.</p> </sec> <sec id="bjo12288-sec-0005" sec-type="section"> <title>Methods</title> <p>Hp phenotype was determined in white women who completed the study and had plasma samples available (<italic>n</italic> = 685).</p> </sec> <sec id="bjo12288-sec-0006" sec-type="section"> <title>Main outcome measure</title> <p>Pre‐eclampsia.</p> </sec> <sec id="bjo12288-sec-0007" sec-type="section"> <title>Results</title> <p>Compared with Hp 2‐1, Hp 1‐1 (OR 0.59, 95% CI 0.30–1.16) and Hp 2‐2 (OR 0.93, 95% CI 0.60–1.45) were not associated with significantly decreased pre‐eclampsia risk after adjusting for treatment group and HbA1c at randomisation. Our study was not powered to detect an interaction between Hp phenotype and treatment response; however, our preliminary analysis suggests that vitamins C and E did not prevent pre‐eclampsia in women of any Hp phenotype (Hp 1‐1, OR 0.77, 95% CI 0.22–2.71; Hp 2‐1, OR 0.81, 95% CI 0.46–1.43; Hp 2‐2, 0.67, 95% CI 0.34–1.33), after adjusting for HbA1c at randomisation.</p> </sec> <sec id="bjo12288-sec-0008" sec-type="section"> <title>Conclusions</title> <p>The Hp phenotype did not significantly affect pre‐eclampsia risk in women with type‐1 diabetes.</p> </sec> </abstract>