The relationship between electrospray ionization behavior and cytotoxic activity of [MI(P)4]+‐type complexes (M = Cu, Ag and Au; P = tertiary phosphine). (29th July 2013)

• Record Type: Journal Article
• Authors: Tisato, Francesco; Crociani, Laura; Porchia, Marina; Bernardo, Plinio Di; Endrizzi, Francesco; Santini, Carlo; Seraglia, Roberta
• Is Part Of: Rapid communications in mass spectrometry. Volume 27:Number 17(2013)
• Page Start: 2019
• Page End: 2027
• Publication Date: 2013-07-29
• Subjects: Mass spectrometry -- Periodicals; 543.65
• DOI: 10.1002/rcm.6661
• Languages: English
• ISSNs: 0951-4198

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="rcm6661-sec-0001" sec-type="section"> <title>RATIONALE</title> <p>To try to find a correlation between the antiproliferative activity of a series of [M<sup>I</sup>(P)<sub>4</sub>]<sup>+</sup> complexes (M = Cu, Ag and Au; P = tertiary phosphine) and their stability at micromolar concentration under mass spectrometric conditions.</p> </sec> <sec id="rcm6661-sec-0002" sec-type="section"> <title>METHODS</title> <p>[M<sup>I</sup>(P)<sub>4</sub>]<sup>+</sup> complexes were investigated by positive ion electrospray ionization mass spectrometry with multiple collisional experiments using an ion trap mass spectrometer.</p> </sec> <sec id="rcm6661-sec-0003" sec-type="section"> <title>RESULTS</title> <p>The displacement of P from native [M<sup>I</sup>(P)<sub>4</sub>]<sup>+</sup>, previously described for the copper derivative, is common for the triad complexes leading to the formation of [M(P)<sub>3</sub>]<sup>+</sup> and [M(P)<sub>2</sub>]<sup>+</sup> adducts. Further dissociation of [M(P)<sub>2</sub>]<sup>+</sup> depends on the nature of the metal (Cu ~ Ag > Au). More labile [Cu(P)<sub>2</sub>]<sup>+</sup> and [Ag(P)<sub>2</sub>]<sup>+</sup> are more cytotoxic against HCT‐15 human colon carcinoma cells compared to less labile [Au(P)<sub>2</sub>]<sup>+</sup> species.</p> </sec> <sec id="rcm6661-sec-0004" sec-type="section"> <title>CONCLUSIONS</title> <p>The dissociation of P ligand(s) from the [M<sup>I</sup>(P)<sub>4</sub>]<sup>+</sup> complexes is the driving force for the triggering of the antiproliferative activity. The more favored is the displacement of P from the [M(P)<sub>2</sub>]<sup>+</sup> active form, the more favored is in turn the possibility for the metal to interact with biological substrates related to cancer proliferation. Copyright © 2013 John Wiley & Sons, Ltd.</p> </sec> </abstract>