Association of PPP1R3B polymorphisms with blood lipid and C‐reactive protein levels in a Chinese population (中国汉族人群中PPP1R3B 基因多态性与血脂及C 反应蛋白水平的相关性). (28th May 2013)

• Record Type: Journal Article
• Authors: Zhang, Yongxian; Gan, Wei; Tian, Chuan; Li, Huaixing; Lin, Xu; Chen, Yan
• Is Part Of: Journal of diabetes. Volume 5:Number 3(2013:Jul.)
• Page Start: 275
• Page End: 281
• Publication Date: 2013-05-28
• Subjects: Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12028
• Languages: English
• ISSNs: 1753-0393

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jdb12028-sec-0001" sec-type="section"> <title>Background</title> <p>Genetic variants of <italic>PPP1R3B</italic>, a gene encoding a critical protein involved in hepatic glycogen metabolism, were recently reported to be associated with plasma levels of lipids and C‐reactive protein (CRP) among populations of mostly European descent. The aim of the present study was to investigate whether the <italic>PPP1R3B</italic> variants are associated with plasma levels of lipids and inflammation factors in Chinese Han.</p> </sec> <sec id="jdb12028-sec-0002" sec-type="section"> <title>Methods</title> <p>Five single nucleotide polymorphisms (SNPs) of the <italic>PPP1R3B</italic> gene were genotyped and their associations with plasma lipids and CRP were determined in 1636 Chinese Han from Shanghai.</p> </sec> <sec id="jdb12028-sec-0003" sec-type="section"> <title>Results</title> <p>Three SNPs, namely rs2126259, rs9987289, and rs19334, were significantly associated with plasma levels of low‐density lipoprotein–cholesterol, and rs2126259 and rs9987289 were further significantly associated with total cholesterol. The remaining two SNPs (rs189798 and rs330919) were significantly associated with plasma CRP levels, but not with plasma lipid levels.</p> </sec> <sec id="jdb12028-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Genetic polymorphisms of the <italic>PPP1R3B</italic> gene may contribute to variations in plasma lipids and CRP levels among Chinese Han individuals.</p> </sec> </abstract>