Prostaglandin E2 and nitric oxide mediate the acute inflammatory (erythemal) response to topical 5‐aminolaevulinic acid photodynamic therapy in human skin. (30th August 2013)

• Record Type: Journal Article
• Authors: Brooke, R.C.C.; Sidhu, M.; Sinha, A.; Watson, R.E.B.; Friedmann, P.S.; Clough, G.F.; Rhodes, L.E.
• Is Part Of: British journal of dermatology. Volume 169:Number 3(2013:Sep.)
• Page Start: 645
• Page End: 652
• Publication Date: 2013-08-30
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.12562
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="short" xml:lang="en" id="bjd12562-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> </p> <p> <list id="bjd12562-list-0001" list-type="bullet"> <list-item> <p>An acute inflammatory response is clinically observed following topical 5‐aminolaevulinic acid (ALA) photodynamic therapy (PDT).</p> </list-item> <list-item> <p>Histamine mediates the immediate reaction, but the mediators of the prolonged erythemal response are unknown.</p> </list-item> <list-item> <p>Prostaglandin (PG)E₂ and nitric oxide (NO) are released following PDT in experimental models, where they can influence the therapeutic response to PDT.</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> </p> <p> <list id="bjd12562-list-0002" list-type="bullet"> <list-item> <p>PGE₂ and NO are released in healthy human skin following topical 5‐ALA‐PDT.</p> </list-item> <list-item> <p>The role of these mediators in the clinical inflammatory response of human skin to 5‐ALA‐PDT is demonstrated by the application of topical inhibitors.</p> </list-item> <list-item> <p>The potential significance of these mediators in the response to PDT in human cutaneous pathology warrants study.</p> </list-item> </list> </p> </abstract>