MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results. (November 2013)

• Record Type: Journal Article
• Authors: Betoni, James S.; Derr, Kimberly; Pahl, Matthew C.; Rogers, Laura; Muller, Corinna L.; Packard, Roger E.; Carey, David J.; Kuivaniemi, Helena; Tromp, Gerard
• Is Part Of: Hypertension in pregnancy. Volume 32:Number 4(2013)
• Page Start: 321
• Page End: 339
• Publication Date: 2013-11
• Subjects: Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.3109/10641955.2013.807819
• Languages: English
• ISSNs: 1064-1955

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objective</italic>: The aim was to identify differences in microRNA expression between patients with and without preeclampsia. <italic>Methods</italic>: Microarray-based study was carried out with placental samples. <italic>Results</italic>: Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however, were seen in more than one study and the results agreed in the direction of change. Bioinformatic analysis of these 20 microRNAs identified a wide range of biological functions including apoptosis and cell movement for their mRNA targets. <italic>Conclusion</italic>: The associations between miRNA expression and preeclampsia suggest a potential role for microRNAs in preeclampsia pathobiology.</p> </abstract>