Preparation and in vitro percutaneous penetration of simvastatin ethosome gel. (October 2013)

• Record Type: Journal Article
• Authors: An, Keyao; Sun, Yong; Wu, Yan; Yuan, Haicheng; Cui, Zhaoyuan; Xu, Lisa
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 41:Number 5(2013:Oct.)
• Page Start: 315
• Page End: 318
• Publication Date: 2013-10
• Subjects: Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/10731199.2012.743903
• Languages: English
• ISSNs: 2169-1401

Abstract

<abstract> <title>Abstract</title> <p>To prepare ethosome gel containing simvastatin ethosome and investigate the permeation behavior of simvastatin from ethosome gel. Cumulative permeation quantity in unit area and intradermal retention were the indicators to evaluate the effects of simvastatin in vitro percutaneous permeation behavior. Cumulative permeation quantity in unit area of simvastatin ethosome gel was significantly higher than other agents (P &lt; 0.05), the intradermal retention of simvastatin ethosome gel, simvastatin gel containing 1%, and 3% menthol were significantly higher than simvastatin gel (P &lt; 0.05). Ethosome gel could enhance the skin permeation and accumulation in a depot of simvastatin.</p> </abstract>