Synthesis of Novel Pyrano[2, 3‐b]pyridines from α, α′‐Bis(substituted‐benzylidene)cycloalkanones. (18th May 2013)

• Record Type: Journal Article
• Authors: Bigdeli, Mohammad Ali; Marjani, Katayon; Farokhi, Elinaz; Sheikhhosseini, Enayatollah; Ghazanfari, Dadkhoda
• Is Part Of: Journal of heterocyclic chemistry. Volume 50:Number 3(2013:May)
• Page Start: 625
• Page End: 629
• Publication Date: 2013-05-18
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.1612
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In this paper, we describe a two‐step synthesis of a series of tacrine analogues. In the first step, α, α'‐bis(substituted‐benzylidene)cycloalkanones are reacted with malononitrile to afford 2‐amino‐3‐cyano‐4<italic>H</italic>‐pyrans. The second step involves the conversion of pyrans to pyrano[2, 3‐<italic>b</italic>]pyridines with the use of AlCl₃ as catalyst.</p> </abstract>