Serum vascular adhesion protein-1 level is higher in smokers than non-smokers. (September 2013)

• Record Type: Journal Article
• Authors: Wang, Yi-Chia; Li, Hung-Yuan; Wei, Jung-Nan; Lin, Mao-Shin; Shih, Shyang-Rong; Hua, Cyue-Huei; Smith, David J.; Vanio, Jani; Chuang, Lee-Ming
• Is Part Of: Annals of human biology. Volume 40:Number 5(2013:Sep./Oct.)
• Page Start: 413
• Page End: 418
• Publication Date: 2013-09
• Subjects: Human biology -- Periodicals; 612
• DOI: 10.3109/03014460.2013.788679
• Languages: English
• ISSNs: 0301-4460

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background</italic>: Semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) is involved in the pathogenesis of both atherosclerosis and cancer. Because chemical components and metabolites of cigarettes are deaminated by SSAO, the relationship between smoking and serum SSAO/VAP-1 was studied in humans.</p> <p> <italic>Methods</italic>: A total of 451 non-diabetic and normoalbuminuric Han Chinese subjects were recruited to participate in this study. Smoking history was obtained by using a questionnaire and those who smoked more than 100 cigarettes during a 6-month period were considered smokers. Serum VAP-1 concentration was measured by time-resolved immunofluorometric assay. Age, gender, waist circumference and estimated glomerular filtration rate (GFR) were adjusted in different statistical models.</p> <p> <italic>Results</italic>: Smokers were mainly male (85.7% versus 26.3%) and were more obese than non-smokers (<italic>p</italic> < 0.05). Subjects with higher serum VAP-1 concentrations were older (<italic>p</italic> < 0.001) and tended to have larger waist circumferences and lower estimated GFR. Serum VAP-1 concentration was higher in smokers than in non-smokers (<italic>p</italic> < 0.05) after adjusting for age, gender, waist circumference, estimated GFR, liver biochemistry and lipid profile.</p> <p> <italic>Conclusions</italic>: Cigarette smoking is associated with elevated serum VAP-1 concentration. Whether VAP-1 and its SSAO activity link the relationship between cigarette smoking, atherosclerosis and cancer requires further investigation.</p> </abstract>