Whitening and antioxidant activities of bornyl acetate and nezukol fractionated from Cryptomeria japonica essential oil. (6th July 2013)

• Record Type: Journal Article
• Authors: Kim, S. H.; Lee, S. Y.; Hong, C. Y.; Gwak, K. S.; Park, M. J.; Smith, D.; Choi, I. G.
• Is Part Of: International journal of cosmetic science. Volume 35:Number 5(2013:Oct.)
• Page Start: 484
• Page End: 490
• Publication Date: 2013-07-06
• Subjects: Cosmetics -- Periodicals; 668.5505
• DOI: 10.1111/ics.12069
• Languages: English
• ISSNs: 0142-5463

Abstract

<abstract abstract-type="main" id="ics12069-abs-0001"> <title>Synopsis</title> <sec id="ics12069-sec-0001" sec-type="section"> <title>Objectives</title> <p>The aim of this study was to investigate the whitening and antioxidant activities of essential oils from <italic>Cryptomeria japonica</italic> by determining their tyrosinase inhibition, 1, 1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging and superoxide dismutase (SOD)‐like activities.</p> </sec> <sec id="ics12069-sec-0002" sec-type="section"> <title>Methods</title> <p>Essential oils of <italic>C. japonica</italic> leaves were extracted with distilled water, and after condensation of volatile constituents, the condensates were extracted with ethyl acetate. Crude essential oils of <italic>C. japonica</italic> were divided into six fractions by thin layer chromatography and open column chromatography, and their chemical analysis was performed by GC/MS. Major compounds of fractions were composed of kaurene, bornyl acetate, nezukol, (‐)‐4‐terpineol, δ‐cadinene, α‐terpineol, γ‐eudesmol, α‐eudesmol and elemol.</p> </sec> <sec id="ics12069-sec-0003" sec-type="section"> <title>Results</title> <p>For tyrosinase inhibitory activity using two substrates, <sc>l</sc>‐tyrosine and 3, 4‐dihydroxyphenylalanine (<sc>l</sc>‐DOPA), kaurene, bornyl acetate and nezukol were highly effective. In antioxidant activity, (‐)‐4‐terpinenol and δ‐cadinene showed high DPPH radical scavenging activity, and bornyl acetate and nezukol indicated extremely high SOD‐like activity.</p> </sec> <sec id="ics12069-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Therefore, bornyl acetate and nezukol fractionated from <italic>C. japonica</italic> essential oil, which showed highly active whitening and antioxidant activities, have potential applications in cosmeceutical materials.</p> </sec> </abstract>