Late‐onset Leber hereditary optic neuropathy. (11th April 2013)

• Record Type: Journal Article
• Authors: Pfeiffer, Margaret L; Hashemi, Nafiseh; Foroozan, Rod; Lee, Andrew G
• Is Part Of: Clinical & experimental ophthalmology. Volume 41:Number 7(2013)
• Page Start: 690
• Page End: 693
• Publication Date: 2013-04-11
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1111/ceo.12091
• Languages: English
• ISSNs: 1442-6404

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="ceo12091-sec-0001" sec-type="section"> <title>Background</title> <p>While Leber hereditary optic neuropathy typically causes bilateral visual loss in the second through fourth decades, we highlight visual loss from Leber hereditary optic neuropathy in older patients to characterize the clinical features of this cohort.</p> </sec> <sec id="ceo12091-sec-0002" sec-type="section"> <title>Design</title> <p>Retrospective case series.</p> </sec> <sec id="ceo12091-sec-0003" sec-type="section"> <title>Participants</title> <p>Patients seen between January 2003 and July 2012 at Baylor College of Medicine and between April 2010 and July 2012 at The Methodist Hospital in Houston, Texas.</p> </sec> <sec id="ceo12091-sec-0004" sec-type="section"> <title>Methods</title> <p>Patients with visual loss from genetically confirmed Leber hereditary optic neuropathy were identified via retrospective chart review.</p> </sec> <sec id="ceo12091-sec-0005" sec-type="section"> <title>Main Outcome Measures</title> <p>Clinical courses of patients.</p> </sec> <sec id="ceo12091-sec-0006" sec-type="section"> <title>Results</title> <p>Five patients with visual loss from genetically confirmed Leber hereditary optic neuropathy were greater than 60 years of age at the time of visual loss (range 62–70 years, mean 66.4 ± 3.0).</p> </sec> <sec id="ceo12091-sec-0007" sec-type="section"> <title>Conclusion</title> <p>This series reinforces the importance of including Leber hereditary optic neuropathy in the differential diagnosis of patients of any age with optic neuropathy.</p> </sec> </abstract>