Synthesis, crystal and electronic structure, anticancer activity of ruthenium(II) arene complexes with thiosemicarbazones. (11th April 2013)

• Record Type: Journal Article
• Authors: Su, Wei; Zhou, Quan; Huang, Yanmin; Huang, Qianyang; Huo, Lini; Xiao, Qi; Huang, Shan; Huang, Chusheng; Chen, Rui; Qian, Quanquan; Liu, Lifeng; Li, Peiyuan
• Is Part Of: Applied organometallic chemistry. Volume 27:Number 5(2013:May)
• Page Start: 307
• Page End: 312
• Publication Date: 2013-04-11
• Subjects: Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.2977
• Languages: English
• ISSNs: 0268-2605

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A series of half‐sandwich ruthenium(II) arene complexes [(<italic>η</italic>⁶‐<italic>p</italic>‐cymene)Ru^II(R‐BzTSC)Cl]Cl <xref ref-type="link" rid="aoc2977-fig-0001">1</xref><xref ref-type="link" rid="aoc2977-fig-0001">1</xref><xref ref-type="link" rid="aoc2977-fig-0001">1</xref> (BzTSC = benzaldehyde thiosemicarbazone and R = H, CH₃ and C₆H₅) have been synthesized and characterized by IR, ¹H NMR, UV‐visible, electrospray ionization mass spectrometry and elemental analysis. The single‐crystal structures of <xref ref-type="link" rid="aoc2977-fig-0001">1</xref> and <xref ref-type="link" rid="aoc2977-fig-0001">1</xref> have been determined. The molecular orbitals and electronic absorption spectra of the compounds have been calculated using the DFT and TDDFT methods. The <italic>in vitro</italic> antiproliferative activities of these complexes have been evaluated against four human cancer cell lines (CNE, H292, SKBR3 and Hey1‐B), and <xref ref-type="link" rid="aoc2977-fig-0001">1</xref> is proved to be the most efficient inhibitor, with IC₅₀ values of 20, 31, 10 and 34 μ<sc>m</sc>, respectively. Copyright © 2013 John Wiley &amp; Sons, Ltd.</p> </abstract>