Challenging The Tritope Model of T cell Receptor Structure–Function Relationships with Classical Data on 'Super' and 'Allo‐MHC' Antigens. (12th September 2013)

• Record Type: Journal Article
• Authors: Cohn, M.
• Is Part Of: Scandinavian journal of immunology. Volume 78:Number 4(2013:Oct.)
• Page Start: 313
• Page End: 324
• Publication Date: 2013-09-12
• Subjects: Immunology -- Periodicals; 571.96
• DOI: 10.1111/sji.12092
• Languages: English
• ISSNs: 0300-9475

Abstract

<abstract abstract-type="main" id="sji12092-abs-0001"> <title>Abstract</title> <p>The response of the immune system to allo‐MHC‐encoded antigens and <italic>Mls</italic> 'superantigens' has been experimentally analysed in detail, but the data have not been coupled to a theoretical framework. It should therefore be instructive to see how well the newly proposed Tritope Model of TCR structure–function relationships deals with the signalling interactions between the TCR and the above antigens. We will pay heed to William Bateson's admonition, 'treasure the exceptions', by showing how a meaningful theory interrogates the data with the same validity that the data interrogate the theory. The concordances, as well as the contradictions, with the Tritope Model are a test of its heuristic value.</p> </abstract>